OBJECTIVES We sought to prospectively compare nitrogen-13 (N)-ammonia/fluorodeoxyglucose (FDG) positron emission tomography (PET)–guided management with stress/rest technetium-99m (Tc)-sestamibi single-photon emission computed tomography (SPECT)– guided management. BACKGROUND Patients with evidence of jeopardized (i.e., ischemic or viable) myocardium may benefit from revascularization, whereas ...

OBJECTIVES Fluorine-18 fluorodeoxyglucose (FDG) SPECT has emerged as an alternative to dedicated PET imaging. However, it remains uncertain whether FDG SPECT is an as accurate for viability assessment as FDG PET in patients with severely reduced left ventricular function. The aim of the study was to assess the diagnostic accuracy of FDG SPECT in a head-to-head comparison with FDG PET, and divid...

UNLABELLED Small-animal nuclear imaging modalities have become essential tools in the development process of new drugs, diagnostic procedures, and therapies. Quantification of metabolic or physiologic parameters is based on pharmacokinetic modeling of radiotracer biodistribution, which requires the blood input function in addition to tissue images. Such measurements are challenging in small ani...

UNLABELLED Brain imaging with glucose ((18)F-FDG) PET or blood flow (hexamethylpropyleneamine oxime) SPECT is widely used for the differential diagnosis of dementia, though direct comparisons to clearly establish superiority of one method have not been undertaken. METHODS Subjects with Alzheimer disease (AD; n = 38) and dementia with Lewy bodies (DLB; n = 30) and controls (n = 30) underwent (...

The combination of PET and SPECT with MRI is an area of active research at present time and will enable new biological and pathological analysis tools for clinical applications and pre-clinical research. Image processing and reconstruction in multi-modal PET/MRI and SPECT/MRI poses new algorithmic and computational challenges. We investigate the use of Probabilistic Graphical Models (PGM) to co...

BACKGROUND AND PURPOSE Patients with focal intractable epilepsy and normal MR imaging findings frequently undergo further diagnostic tests to localize the epileptogenic zone. The aim of this study was to determine the cost-effective diagnostic strategy that will identify the epileptogenic zone in patients with suspected focal intractable epilepsy and normal MR imaging findings by using decision...

PURPOSE To compare the diagnostic value of 99Tcm-MIBI- SPECT and 18F-FDG-PET/CT in differentiating benign from malignant solitary pulmonary nodules (SPNs). METHODS 170 SPNs were involved in this study (78 with 99Tcm-MIBI-SPECT and 92 with 18F-FDG-PET/CT). Definite diagnosis of SPNs was determined by biopsy. The diagnostic efficiency of 99Tcm-MIBI-SPECT and 18F-FDGPET/ CT in differentiating be...

introduction quality control is an important phenomenon in nuclear medicine imaging. a jaszczak spect phantom provides consistent performance information for any spect or pet system. this article describes the simulation of a jaszczak phantom and creating an executable phantom file for comparing assessment of spect cameras using simind monte carlo simulation program which is well-established fo...

The diagnostic performance of rubidium-82 (Rb-82) positron emission tomography (PET) and thallium-201 (Tl-201) single-photon emission-computed tomography (SPECT) for detecting coronary artery disease was investigated in 81 patients (52 men, 29 women). PET studies using 60 mCi of Rb-82 were performed at baseline and after intravenous infusion of 0.56 mg/kg dipyridamole in conjunction with handgr...

Abstract Background The tubarial glands (TGs) are recently reported as newly found salivary gland structures that can be organs at risk predominantly localized in the tori tubarius nasopharynx using prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT). aims of this study were to analyze uptake TGs compared with other and palatine tonsils [ 99m Tc]per...