The metabotropic glutamate receptor type 1 (mGluR1) is a novel target protein for the development of new drugs against central nervous system disorders. Recently, we have developed (11)C-labeled PET probes (11)C-ITMM and (11)C-ITDM, which demonstrate similar profiles, for imaging of mGluR1. In the present study, we compared (11)C-ITMM and (11)C-ITDM PET imaging and quantitative analysis in the ...

Green strategies for late-stage fluorination with (18)F, in which ethanol and water are the only solvents used throughout the entire radiolabeling process (azeotropic drying, nucleophilic fluorination, purification and formulation), have been developed and applied to the radiosyntheses of a range of radiopharmaceuticals commonly employed in clinical PET imaging.

Hypoxia, a deficiency in the levels of oxygen, is common feature most solid tumors and induces many characteristics cancer. Hypoxia associated with metastases strong resistance to radio- chemotherapy, can decrease accuracy cancer prognosis. Non-invasive imaging methods such as positron emission tomography (PET) single-photon computed (SPECT) using hypoxia-targeting radiopharmaceuticals have bee...

In spite of considerable progress, much remains to be done in the estimation of absorbed doses to organs and tissues in the body and in the prediction of biological effects from radiopharmaceuticals. In patients undergoing diagnostic procedures, the biokinetics of the radionuclide has to be determined for a number of representative patients. When radiopharmaceuticals are used for therapy, it is...

Background Cyclotrons form a central infrastructure and are resource of medical radionuclides for the development new radiotracers as well production supply clinically established radiopharmaceuticals patient care in nuclear medicine. Aim To provide an updated overview number characteristics cyclotrons that currently use within radiopharmaceutical sciences to be used Nuclear Medicine Germany (D...

Positron Emission Tomography (PET) is a clinically established noninvasive imaging modality [1]. In PET, targeting ligands, or drug molecules labeled with a positron-emitting isotope, typically known as PET-radiopharmaceuticals, are introduced in to the body at a very low concentration (nanomolar or picomolar range), and are not intended to have any pharmacological effect. As the radioisotope d...

Nuclear cardiology is an extremely important modality in the management of coronary artery disease. Information about myocardial perfusion , myocardial function, myocardial metabolism, myocardial innervation, myocardial infarction and apoptosis , atherosclerosis and gene therapy can be obtained with nuclear cardiology scans.Nuclear cardiology involves use of radiopharmaceuticals to study the fu...