Pancreatic enzyme replacement therapy (PERT) is the only treatment for malabsorption in cystic fibrosis (CF) caused by pancreatic insufficiency (PI). PI occurs in approximately 85% of patients with CF. PERT overcomes some, but not all the signs and symptoms of malabsorption. Clinical parameters such as growth, abdominal pain, diarrhea and gassiness, commonly used to adjust PERT dosing, are show...

PERT is a widely utilized framework for project management. However, as a result of underlying assumptions about the activity times, the PERT formulas prescribe a light-tailed distribution with a constant variance conditional on the range. Given the pervasiveness of heavy-tailed phenomena in business contexts as well as inherently differing levels of uncertainty about different activities, ther...

We develop a multi-objective model for the resource allocation problem in a dynamic PERT network, where the activity durations are exponentially distributed random variables and the new projects are generated according to a Poisson process. This dynamic PERT network is represented as a network of queues, where the service times represent the durations of the corresponding activities and the arr...

The following analytical approaches: queuing network models, stochastic automata networks, stochastic timed Petri nets, stochastic process algebra, Markov chains can be used in performance evaluation of multi–agent systems. In this paper, new approach which is based on PERT networks is presented. This approach is applied in performance evaluation of layered multi–agent system. Time-out mechanis...

THE STRUCTURE OF A MODEL / 305 CLASSIFICATIONS OF MODELS / 306 COMMON MODELING TECHNIQUES I 307 Flow (harts / 307 Graph or Network Models / 309 PERT Planning Method / 312 Linear Programming Models / 313 Queueing Models / 314 Arrival Process / 314 Queue Structure / 315 Service System / 315 Measures of Performance / 315 Simulation Models / 316 Case Study 1 : Emergency Service Simulation Model / 3...

Received September 15, 1997; revised May 14, 1998; accepted August 20, 1998. Communicated by Jieh Hsiang. 1 A CPM/PERT can be either an AOV or an equivalent AOA (Activity On Arc) network. Here, AOV is adapted for comparison with SPREM. 2 Here, deterministic means that when a process on vertex V is complete, then all of V’s successors will enact the process individually. JOURNAL OF INFORMATION S...

A β-glucuronidase variant, GUS-TR3337, that was obtained by directed evolution exhibited higher thermostability than the wild-type enzyme, GUS-WT. In this study, the utility of GUS-TR337 as an improved reporter was evaluated. The corresponding gus-tr3337 and gus-wt genes were independently cloned in a plant expression vector and introduced into Arabidopsis thaliana. With 4-MUG as a substrate, p...

BACKGROUND Treatment-naïve patients newly diagnosed with HIV occasionally present with low viral RNA of ≤1'000 copies/ml, raising concerns about viral load underestimation. Because falsely low or undetectable viral loads might lead to inadvertent virus transmission or treatment delays, confirmation of such cases by a sequence-independent viral load test is recommended in Switzerland. METHODS ...

Ensemble classifiers originated in the machine learning community. They work by fitting many individual classifiers and combining them by weighted or unweighted voting. The ensemble classifier is often much more accurate than the individual classifiers from which it is built. In fact, ensemble classifiers are among the most accurate general-purpose classifiers available. We introduce a new ense...

This paper describes techniques developed for conflict detection during plan integration. Agents' intensions are represented with intended goal structure (IGS) and the E-PERT diagrams. Conflicts are classified as goal, plan, and belief conflicts. Before integrating individual plans and detecting plan conflicts, agents first detect and eliminate their goal conflicts by exchanging their IGS. Plan...