Renal Unit, St James's University Hospital, Leeds, UK, CHU Lapeyronie, Nephrology, Dialysis, Intensive Care, Montpellier, LR, France, Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Department of Renal Medicine, Karolinska University Hospital, Huddinge, Stockholm, Sweden, Ospedale Bolognini—Seriate, Nefrologia e Dialisi Seriate, It...

background: cellulite is the accumulation of subcutaneous fat and connective tissue in tights and buttocks. xanthines, such as aminophylline, are used as phosphodiesterase inhibitors, and are also adenosine receptor antagonists. objectives: the aim of the present study was to characterize in vitro aminophylline transdermal absorption through shed snake skin, and to investigate the absorption en...

the topical delivery of non-steroidal anti-inflammatory drugs (nsaids) such as ibuprofen has been explored as a potential method of avoiding the first pass effects and the gastric irritation, which may occur when used orally. ibuprofen is formulated into many topical preparations to reduce the adverse effects and simultaneously avoid the hepatic first-pass metabolism as well. however, it is dif...

When the permeability field of a given porous medium domain is heterogeneous by the existence of randomly distributed fractures such that numerical investigation becomes cumbersome, another level of upscaling may be required. That is such complex permeability field could be relaxed i.e., smoothed by constructing an effective permeability field. The effective permeability field is an approximati...

Internal concentration polarization (ICP) in forward osmosis (FO) process is a characteristic problem for asymmetric thin-film composite (TFC) FO membrane which leads to lower water flux. To mitigate the ICP effect, modification of the substrates' properties has been one of the most effective methods. A new polyethersulfone-based ultrafiltration membrane with increased surface porosity and high...

Determining the mechanisms of flux through protein channels requires a combination of structural data, permeability measurement, and molecular dynamics (MD) simulations. To further clarify the mechanism of flux through aquaporin 1 (AQP1), osmotic p(f) (cm(3)/s/pore) and diffusion p(d) (cm(3)/s/pore) permeability coefficients per pore of H(2)O and D(2)O in AQP1 were calculated using MD simulatio...

Plasmodesmata permit solutes to move between cells nonspecifically and without having to cross a membrane. This symplastic connectivity, while straightforward to observe using fluorescent tracers, has proven difficult to quantify. We use fluorescence recovery after photobleaching, combined with a mathematical model of symplastic diffusion, to assay plasmodesmata-mediated permeability in the Ara...

A dual-pathway model is proposed for transport across the tight junction (TJ) in rat proximal tubule: large slit breaks formed by infrequent discontinuities in the TJ complex and numerous small circular pores, with spacing similar to that of claudin-2. This dual-pathway model is developed in the context of a proximal tubule model (Weinstein AM. Am J Physiol Renal Fluid Electrolyte Physiol 247: ...

Wood has better load-bearing capacity following the formation of a char layer when exposed to fire. The charring rate is the most important property of wood with respect to its fire resistance and fire integrity. The objectives of this study were to determine the effects of factors, including density, gas permeability, ring width, grain orientation, and heat flux, on the charring rate. The char...

Chitosan/polyethersulfone (CS/PES) composite membrane was prepared from casting chitosan solution on polyethersulfone substrate membrane. The Substrate membrane was prepared by phase inversion technique using polyethersulfone (PES) and dimethylacetamide (DMAc) as solvent with and without the addition of polyvinylpyrrolidone (PVP) as pore-forming agent. The effects of the composition of the c...