Background: Congenital hypothyroidism is inadequate thyroid hormone production in newborn infants. This can occur because of an anatomic defect in the gland, an inborn error of thyroid metabolism, or iodine deficiency. Thyroid hormone treatment in children with congenital hypothyroidism can prevent intellectual disability. Guidelines recommend that children with congenital hypothyroidism throug...

background & aim: congenital hypothyroidism (ch) is one of the most common endocrine diseases and is a major cause of preventable mental retardation. early diagnosis of ch can help prevent future diseases. although time series techniques are often utilized to forecast future status, they are inadequate to deal with count data with overdispersion. the aim of this study was to apply poisson hidde...

Johanson Blizzard syndrome (JBS) is a rare multi-system disorder characterized by congenital aplasia or hypoplasia of alae nasi, exocrine pancreatic insufficiency, hypothyroidism, deafness, growth retardation, varying degree of mental retardation, alopecia, wide open fontanels, anti-mongoloid slant, café-au-lait spots and absent of permanent teeth. We report a 3 months old male child having Joh...

‘Screening window’, defined as the period between the development of the abnormal test result of NBS and development of symptoms in the infant, may vary from disorder to disorder. It will be most ideal to collect sample on fourth day of life. Samples can be collected from home by trained nurse/phlebotomist. There are many riders associated with interpretation of blood samples collected in the f...

OBJECTIVE Congenital hypothyroidism is characterized by inadequate thyroid hormone production in newborn infants. Many infants with CH have co-occurring congenital malformations. This is an investigation on the frequency and types of congenital anomalies in infants with congenital hypothyroidism born from May 2006-2010 in Hamadan, west province of Iran. METHODS The Iranian neonatal screening ...

Congenital hypothyroidism occurs in approximately 1 in 2000 newborns and can have devastating neurodevelopmental consequences if not detected and treated promptly. While newborn screening has virtually eradicated intellectual disability due to severe congenital hypothyroidism in the developed world, more stringent screening strategies have resulted in increased detection of mild congenital hypo...

Congenital hypothyroidism is a preventable cause of mental retardation. Since clinical signs of congenital hypothyroidism do not generally become obvious before three months of age, screening programmes have been introduced in North America and Europe, which consist of T4 or TSH screening on newborn infants on the third day of life. The screening for congenital hypothyroidism was initiated in P...

Background & Aims: Thyroid hormones are of great importance in the development of the central nervous system. Congenital hypothyroidism may affect the reorganization of specific and non-specific thalamocortical afferents to whisker–related sensory (wS1) corticol region in rats. Methods: Congenital hypothyroidism was induced by adding propylthiouracil (PTU) (25 ppm) to the rats...