Natural killer (NK) cells are thought to provide the first line of defence against tumors, particularly major histocompatibility complex (MHC) class I- variants. We have confirmed in C57BL/6 (B6) mice lacking perforin that peritoneal growth of MHC class I- RMA-S tumor cells in unprimed mice is controlled by perforin-dependent cytotoxicity mediated by CD3(-) NK1.1(+) cells. Furthermore, we demon...

RATIONALE Accessory spleen is a congenital abnormality caused by failure of the splenic anlage to fuse during embryology. The presence of an accessory spleen located in the parietal peritoneum has not been reported so far, and an accessory spleen situated on the right side is extremely rare. In the present study, we describe the first case of an accessory spleen located in the right parietal pe...

The peritoneum is the largest serous membrane of the body. It is a completely closed sac in the male and opens to the exterior through the genital tract in the female. It is lined by simple squamous epithelium called mesothelium. It secretes a small quantity of serous fluid, which eases the movement of the movable organs of the abdomen. The abdominal and pelvic organs are classified as extraper...

BACKGROUND Caesarean section is a very common surgical procedure worldwide. Suturing the peritoneal layers at caesarean section may or may not confer benefit, hence the need to evaluate whether this step should be omitted or routinely performed. OBJECTIVES The objective of this review was to assess the effects of non-closure as an alternative to closure of the peritoneum at caesarean section ...

Extraovarian papillary serous carcinoma of the peritoneum is a rare malignancy characterized by peritoneal carcinomatosis presenting with abdominal pain and ascites. This tumor is similar to serous ovarian carcinoma in context to its clinical presentation, histologic appearance, pattern of spread, treatment and prognosis. We hereby report two cases of extraovarian papillary serous carcinoma of ...

The truth of the statement that the vermiform appendix is a totally intra-peritoneal structure appears to have been satisfactorily demonstrated. There are, however, numerous published statistics which appear to show that a portion of the appendix may be uncovered by peritoneum in a natural state of the parts. Fowler writes: "The completeness with which this [the peritoneum] covers the organ var...

This study was undertaken to gain better insights into the role of TLRs and MyD88 in the development and differentiation of memory B cells, especially of ASC, during the Th2 polarized memory response induced by Natterins. Our in vivo findings demonstrated that the anaphylactic IgG1 production is dependent on TLR2 and MyD88 signaling, and that TLR4 acts as adjuvant accelerating the synthesis of ...

BACKGROUND Injury to the peritoneum during surgery is followed by a healing process that frequently results in the attachment of adjacent organs by a fibrous mass, referred commonly as adhesions. Because injuries to the peritoneum during surgery are inevitable, it is imperative that we understand the mechanisms of adhesion formation to prevent its occurrence. This requires thorough understandin...