Patients with pseudohypoparathyroidism type Ib (PHP-Ib) have hypocalcemia and hyperphosphatemia due to renal parathyroid hormone (PTH) resistance, but lack physical features of Albright hereditary osteodystrophy. PHP-Ib is thus distinct from PHP-Ia, which is caused by mutations in the GNAS exons encoding the G protein alpha subunit. However, an imprinted autosomal dominant form of PHP-Ib (AD-PH...

Background: Although there have been some case reports suggesting that bone in patients with pseudohypoparathyroidism (PHP) might respond to parathyroid hormone (PTH), no information is available as to whether serum PTH concentration is related to bone metabolic markers or to bone mineral density (BMD) in PHP. Objective: To address these relationships, by comparing intact serum PTH, bone metabo...

Background: Retained appendicolith related abscess formation is rare and carries challenging management options. We describe a unique case of a patient who presented with right upper quadrant pain tenderness that is clinically mimicking acute cholecystitis which turned out to be a perihepatic abscess caused by a dropped migrated appendicolith two and half years following a laparoscopic appendec...

As an open source server-side scripts language, PHP is used more and more widely by Web developers now. Protecting PHP code from being plagiarized is also a hot research issue especially with the rapid development of dynamic web industry and people’s copyright protection consciousness. Usually the developers use PHP encoders to encrypt the PHP codes before selling them out. There are several di...

Pseudohypoparathyroidism (PHP) is characterized by hypocalcemia and hyperphosphatemia due to resistance to parathyroid hormone (PTH). Patients with PHP-Ia often present with additional hormonal resistance and show characteristic physical features that are collectively termed Albright's hereditary osteodystrophy (AHO). These features are also present in pseudopseudohypoparathyroidism (PPHP), but...

Introduction: This study developed and tested theory to gain a better understanding of the factors influencing positive health practices (PHP) among Asian American adolescents. Theoretical relationships postulated among (a) PHP and (b) self-esteem (SE), and (c) social support (SS) were tested. Objective: Based on the theoretical and empirical linkages found in the literature between SE and PHP,...

CONTEXT Pseudohypoparathyroidism type 1b (PHP-Ib) is characterized by renal resistance to PTH (and, sometimes, a mild resistance to TSH) and absence of any features of Albright's hereditary osteodystrophy. Patients with PHP-Ib suffer of defects in the methylation pattern of the complex GNAS locus. PHP-Ib can be either sporadic or inherited in an autosomal dominant pattern. Whereas familial PHP-...

In this paper, the effects of container size on the porosity of random loose packing of mono size particles have been investigated using an Event Dynamics (ED) based model. Simultaneous effects of square container walls on particles packing and their order are also investigated. Our simulation results indicate higher container size will increase the total packing factor and high density regions...

[Formula: see text]-Helical transmembrane proteins are the most important drug targets in rational drug development. However, solving the experimental structures of these proteins remains difficult, therefore computational methods to accurately and efficiently predict the structures are in great demand. We present an improved structure prediction method TMDIM based on Park et al. (Proteins 57:5...