Macrophages are major constituents of periapical granulomas. They have a central protective role in both innate immunity and adoptive, antigen-specific immune response. Macrophage activation may occur in periapical granulomas by cytokines produced by antigen-activated T-lymphocytes; by bacterial endotoxin, as part of the innate immunity; or by both these processes. Recent studies in athymic ani...

introduction: bacterial infection of tooth pulp can progress into periapical diseases. root canal treatment has been established as the best treatment. in cases of failure, nonsurgical retreatment of teeth is preferred to surgical procedure and extraction. materials & methods: in this historical cohort study, 104 permanent teeth with apical lesion were treated during 2002-2008. all teeth showed...

PURPOSE This study was performed to investigate the effect of image enhancement of periapical radiographs according to the diagnostic task. MATERIALS AND METHODS Eighty digital intraoral radiographs were obtained from patients and classified into four groups according to the diagnostic tasks of dental caries, periodontal diseases, periapical lesions, and endodontic files. All images were enha...

AIM To test the ability of periapical radiography (PA) and cone-beam computed tomography (CBCT) to determine the presence/absence of periapical lesions and examine the reliability of volumetric measurements of periapical lesions on CBCT scans. METHODOLOGY After tooth extractions in human mandibles, bone defects were cut at the base of extraction sockets to mimic periapical bone lesions. The t...

b a u c g picoectomy involves the surgical management of tooth with a periapical lesion which cannot be esolved by conventional endodontic treatment root canal therapy or endodontic retreatment). ecause the term “apicoectomy” consists of only ne aspect (removal of root apex) of a complex eries of surgical procedures, the terms “periapical urgery” or “periradicular surgery” are more approriate. ...

Implant periapical lesions are infectious-inflammatory alterations surrounding an implant apex, and can be caused by a number of situations--including contamination at instrumentation, overheating of bone, and the prior existence of bone pathology. The diagnosis is based on the clinical manifestations and radiological findings, where a radiotransparency can be seen at periapical level. The lesi...

Abstract Bisphosphonates remain the most used and effective drugs for treatment of systemic bone diseases followed by resorption. Although their side effects in a form alveolar osteonecrosis have been reported, bisphosphonates potential being common oral resorption such as peri-implantitis, periapical lesions, periodontitis. The aim this article was to review recent research regarding use field...

This article reports non-surgical endodontic retreatment of two patients with persistent or recurrent periapical lesions, who had previously undergone surgical and non-surgical endodontic therapy respectively. It further discusses and reviews the relevance of classification of periapical lesions, the explanation behind healing of periapical lesions by endodontic therapy alone, causes of persist...

The purpose of the study was to histologically analyse transition from pulpitis to periapical periodontitis on dog's teeth. Pulps of mandibular premolars (37 roots) were exposed using a low-speed handpiece. Teeth were left open to the oral environment for 20, 35, 50 and 65 days. After the experimental period animals were sacrificed. Undemineralised teeth with surrounding bone, embedded in methy...