Expressed immunoglobulin (Ig) genes undergo alterations in sequence and genomic structure in order to optimize antibody function.A singleB cellspecific factor, activation-induced deaminase (AID), initiates these changes by deamination of cytosine to uracil. Uracil in DNA is encountered commonly, and conserved pathways are responsible for its faithful repair.However, at the Ig loci of B cells,AI...

An app developed by a private firm and customised by a hospital trust has been helping senior nurses carry out ward inspections.

In this paper we study the family of oriented transitive 3–hypergraphs that arrive from cyclic permutations and intervals in the circle to search for the notion of perfection on hypergraphs.

We analysed the structural properties of protein regions containing arrays of perfect and nearly perfect tandem repeats. Naturally occurring proteins with perfect repeats are practically absent among the proteins with known 3D structures. The great majority of such regions in the Protein Data Bank are found in the proteins designed de novo. The abundance of natural structured proteins with tand...

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The reflections in this article answer two related questions. First, is perfection compatible with the “imperfection” of being vulnerable? Second, what role does vulnerability play Christian educational paradigm?To address these questions, concept will be discussed. Then discussed, from perspective theology. Lastly, brush strokes a proposal offered, that incorporates into classical paradigm (pa...

The first 2 PARI-GP files below give the sets of vertices and edges of the Voronoi graph first in dimensions 2 to 6, then in dimension 7. The numerical data are extracted from Jaquet’s thesis [Ja]. The third file, based on Chapters 9 and 14 of [Mar], is devoted to minimal classes in dimensions 2 to 4. We present below a short account of Voronoi’s theory and minimal classes. 1. The perfection ra...

this paper seeks to address the issue of alienation from the perspective of mulla sadra. although mulla sadra did not explicitly employed the term alienation, equivalent terms, such as self-forgetfulness, negligence and self-unconsciousness can be found in his works. the outcome of the study is that mulla sadra is pursuing excellence and perfection of human beings through transcendent philosoph...