نتایج جستجو برای: per1

تعداد نتایج: 620  

Journal: :FEMS microbiology letters 1992
V I Titorenko H R Waterham P Haima W Harder M Veenhuis

In Hansenula polymorpha, different monogenic recessive mutations mapped in either of two previously identified genes, PER1 and PER3, produced different peroxisomal mutant phenotypes. Among five per1 mutants, four showed a Pim- phenotype: the cells contained few small peroxisomes while the bulk of the matrix enzymes resided in the cytosol. One of these mutants, per1-124 had an enhanced rate of p...

Journal: :The European journal of neuroscience 2003
Lance J Kriegsfeld Ruslan Korets Rae Silver

The circadian clock located in the suprachiasmatic nuclei (SCN) of the hypothalamus regulates daily temporal organization in behaviour and neuroendocrine function. The molecular basis for circadian rhythm generation is an interacting transcriptional/translational feedback loop comprised of several 'clock genes' and their respective protein products. Clock genes are expressed not only in the SCN...

Journal: :EMBO reports 2007
Hong Seok Shim Hyunjung Kim Jiwon Lee Gi Hoon Son Sehyung Cho Tae H Oh Sang Hyeon Kang Dong-Seung Seen Kun Ho Lee Kyungjin Kim

In mammals, immediate-early transcription of the Period 1 (Per1) gene is crucial for resetting the mammalian circadian clock. Here, we show that CLOCK is a real signalling molecule that mediates the serum-evoked rapid induction of Per1 in fibroblasts through the Ca2+-dependent protein kinase C (PKC) pathway. Stimulation with serum rapidly induced nuclear translocation, heterodimerization and Se...

Journal: :The European journal of neuroscience 2006
Karen L Gamble Ketema N Paul Mary C Karom Gianluca Tosini H Elliott Albers

The circadian clock in the suprachiasmatic nucleus (SCN) is synchronized by the 24 h, light : dark cycle, and is reset by photic and non-photic cues. The acute effects of light in the SCN include the increase of mRNA levels of the circadian clock gene Per1 and a dramatic reduction of pineal melatonin. Neuropeptide Y (NPY), which appears to mediate the phase-resetting effects of non-photic stimu...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2006
Michael T Sellix Marcel Egli Maristela O Poletini De'Nise T McKee Matthew D Bosworth Cheryl A Fitch Marc E Freeman

Oscillations of gene expression and physiological activity in suprachiasmatic nucleus (SCN) neurons result from autoregulatory feedback loops of circadian clock gene transcription factors. In the present experiment, we have determined the pattern of PERIOD1 (PER1), PERIOD2 (PER2), and CLOCK expression within neuroendocrine dopaminergic (DAergic) neurons (NDNs) of ovariectomized (OVX) rats. We h...

2015
Zhuqin Gu BinBin Wang Yong-Biao Zhang Hui Ding Yanli Zhang Jun Yu Mingliang Gu Piu Chan Yanning Cai

Circadian disruptions may result in sleep problems, oxidative stress and an altered inflammatory response. These symptoms may contribute to PD pathogenesis, despite a lack of direct experimental evidence supporting this relationship. Clock genes are essential to drive and maintain circadian rhythm. To elucidate the possible role of circadian disruptions in PD, we investigated 132 tag variants i...

2012
Jungtae Na Kwanghyun Lee Hwan-Gon Kim Jee-Yoon Shin Wonho Na Hayan Jeong Jong-Woo Lee Sehyung Cho Won-Sun Kim Bong-Gun Ju

Circadian clocks are the endogenous oscillators that regulate rhythmic physiological and behavioral changes to correspond to daily light-dark cycles. Molecular dissections have revealed that transcriptional feedback loops of the circadian clock genes drive the molecular oscillation, in which PER/CRY complexes inhibit the transcriptional activity of the CLOCK/BMAL1 heterodimer to constitute a ne...

Journal: :Journal of biological rhythms 2002
Judy McKinley Brewer Paola C Yannielli Mary E Harrington

Neuropeptide Y (NPY), present in an input pathway to the suprachiasmatic nuclei (SCN), can block the effects of light on circadian rhythms. The authors have studied this interaction using an in vitro brain slice technique. Effects of NPY on light-induced period1 and period2 mRNA in the SCN were examined in vitro following a light pulse during early subjective night. Golden hamsters (n = 91) wer...

Journal: :Endocrinology 2006
Jan Fahrenkrug Birgitte Georg Jens Hannibal Peter Hindersson Søren Gräs

Circadian rhythms are generated by endogenous clocks in the central brain oscillator, the suprachiasmatic nucleus, and peripheral tissues. The molecular basis for the circadian clock consists of a number of genes and proteins that form transcriptional/translational feedback loops. In the mammalian gonads, clock genes have been reported in the testes, but the expression pattern is developmental ...

Journal: :Neuroscience 2009
C Ramanathan A Campbell A Tomczak A A Nunez L Smale L Yan

Photic responses of the circadian system are mediated through light-induced clock gene expression in the suprachiasmatic nucleus (SCN). In nocturnal rodents, depending on the timing of light exposure, Per1 and Per2 gene expression shows distinct compartmentalized patterns that correspond to the behavioral responses. Whether the gene- and region-specific induction patterns are unique to nocturna...

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