Anticonvulsant activity of the methanolic extract of Prosopis Cineraria (Linn) Druce stem barks was studied against maximal electro shock (MES) and Pentylenetetrazole (PTZ) induced convulsions in mice. The extract suppressed hind limb tonic extensions (HLTE) induced by MES and also exhibited Protector Effect in PTZInduced Seizures. In conclusion, the methanolic extract of Prosopis Cineraria (Li...

Sudden unexpected death in epilepsy (SUDEP) is the leading cause of mortality patients with intractable epilepsy. However, pathogenesis SUDEP seems to be poorly understood. Our previous findings showed that incidence seizure-induced respiratory arrest (S-IRA) was markedly reduced by atomoxetine a murine model. Because central norepinephrine ?-1 receptor (NE?-1R) plays vital role regulating func...

Pentylenetetrazole (PTZ) is a chemical substance which largely used for the induction of seizure and epilepsy in animal model, it can also, disrupts free radicals balance cause oxidative stress body with negative impact on memory learning. In this study, medicinal plant Buxus hyrcana, was to evaluate its effect deficit caused by PTZ rats. Twenty-four rats were randomly allocated 4 groups: contr...

Alterations in the NO pathway play an important role in the development of convulsive seizures via the glutamatergic and GABAergic systems in acute pentylenetetrazole (PTZ) seizure animals. We previously reported that the background NO levels under physiological conditions negatively regulate convulsive seizures, while excess NO levels under pathologic conditions positively regulate PTZ-induced...

BACKGROUND An important role for oxidative stress, as a consequence of epileptic seizures, has been suggested. Coriandrum sativum has been shown that have antioxidant effects. Central nervous system depressant effects of C. sativum have also been reported. In this study, the effects of hydroalcoholic extract of aerial parts of the plants on brain tissues oxidative damages following seizures ind...

It is believed that a deficiency of androgens, including free testosterone, may promote the development of convulsions. The present study revealed differences in the action of androsterone (AND), a major excreted metabolite of testosterone and a neurosteroid, in three commonly used seizure models in mice. AND administered intraperitoneally exhibited dose-dependent protection against tonic-cloni...

PURPOSE To characterize the interaction between tiagabine (TGB) and valproate (VPA)--two antiepileptic drugs in the mouse pentylenetetrazole (PTZ)-induced clonic seizure model, type I isobolographic analysis for non-parallel dose-response relationship curves (DRRCs) was used. MATERIAL AND METHODS Clonic seizures were evoked in albino Swiss mice by subcutaneous injection of PTZ at its CD97 (10...

PURPOSE Zebrafish are a vertebrate organism ideally suited to mutagenesis screening strategies. Although a genetic basis for seizure susceptibility and epilepsy is well established, no efforts have been made to study seizure resistance. Here we describe a novel strategy to isolate seizure-resistant zebrafish mutants from a large-scale mutagenesis screen. METHODS Seizures were induced with pen...

The anticonvulsant activity of BmK AS, a sodium channel site 4-selective modulator purified from scorpion venom (Buthus martensi Karsch), was investigated in unanesthetized rats with acute pentylenetetrazole (PTZ)- and pilocarpine-induced seizures. Rats were microinjected in the CA1 region with either saline or BmK AS, followed by epileptogenic doses of PTZ or pilocarpine 30 minutes later. The ...

Adenosine is an endogenous modulator of brain functions, which presents anticonvulsant properties. In addition, its levels can be increased during neural injury. The modulation of extracellular adenosine levels by ectonucleotidase and adenosine deaminase (ADA) activities may represent a key mechanism in the control of epileptogenesis. In the present study, we investigated the effects of acute s...