Central haemodynamic changes and regional blood flow were studied using the microsphere technique, during labetalol-induced hypotension in dogs anaesthetized with pentobarbitone and fentanyl. Labetalol 15 mg kg-1 decreased mean arterial pressure from an average of 88 mm Hg to 47 mm Hg. Mean pulmonary arterial pressure was unchanged. Cardiac output was reduced by decrease in stroke volume, while...

Aqueous, light petroleum, chloroform, alcohol, benzene and acetone extracts of the leaves of Coccinia indica. (Family: Cucurbitaceae) were screened for antihepatotoxic activity. The extracts were given after the liver was damaged with Ccl4 Liver function was assessed based on liver to body weight ratio pentobarbitone sleep time, serum levels of transaminase (SGPT, SGOT), alkaline phosphatase (S...

Meprobamate (2-methyl-2-n-propyl-1, 3-propanediol dicarbamate) was synthesized by Ludwig and Piech (1951). It is an interneuronal blocking agent capable of producing muscular relaxation without affecting respiration or other vital activities (Berger, 1954). The drug produces restful sleep and generalized muscular relaxation (Borrus, 1955). It was decided to test its effect, compared with that o...

All of the anesthetic (amylobarbitone, butobarbitone, pentobarbitone, phenobarbitone, and secobarbitone) and convulsant (5-ethyl-5(3'-methylbut-2-enyl) barbituric acid (3M2B) and 5-ethyl-5-(2'-cyclohexylidene-ethyl) barbituric acid (CHEB) barbiturates tested enhanced the binding of GABA to a carefully prepared P2 membrane fraction from rat brain in a dose-dependent manner. These findings are in...

Benzamido (alkyl) methyl pyrrolidine Mannich bases were synthetized and subjected to certain neuropharmacological studies. All the bases reduced the pentobarbitone sleeping time and rota-rod grip of rats. The Mannich bases II, III and V raised the minimal electro-shock seizure threshold of rats. The TAB-induced pyrexia was not reduced by the bases I and III in rabbits. None of the bases showed ...

Kato and Chiesara (7) reported that many centrally active agents may produce tolerance to barbiturates as a result of induction of liver microsomal enzymes involved in drug metabolism Haloperidol and promethazine have also been reported to influence the enzyme activity (6). As there is lack of information concerning the effect of various psycho-active agents on metabolic mechanisms, it was thou...

The new 4'- hydroxy and 3'- aldehyde phase- 1 metabolites of butobarbitone and pentobarbitone are fully synthesized for the first time. These metabolites were used to idenfity and quantify the natural metabolites in human urine after single and multiple doses of these drugs. The synthesized metobolites have spectral characterizations (IR, NMR, U.V. and mass spectroscopy) consisted with the ...