− Perillae Herba has been traditionally used for the sedation in the oriental countries. Therefore, this study was conducted to determine whether Perillae Herba ethanol extract (PHEE) enhances pentobarbital-induced sleeping behaviors in animals. In addition, the possible mechanisms are demonstrated. PHEE (12.5, 25 and 50 mg/kg. p.o.) reduced the locomotor activity in mice. PHEE reduced sleep la...

background: coriandrum sativum l. has been recommended for relief of insomnia in iranian traditional medicine. however, no pharmacological studies have yet evaluated its sedative effects. the aim of this study was to determine if extracts and essential oil of coriander seeds have sedative-hypnotic activity.   methods: the aqueous or hydro-alcoholic extracts or essential oil of coriander seeds (...

BACKGROUND Anesthetic endpoints of unconsciousness and immobility result from agent effects on both brain and spinal cord that are difficult to separate during systemic administration. To investigate cerebral mechanism of anesthetic-induced unconsciousness, the authors studied behavioral and electrophysiologic effects of four anesthetics infused intracerebroventricularly to conscious rats. The ...

Introduction. Mild hypotension is a well-recognized complication of intravenous pentobarbital; however fulminant cardiopulmonary failure has not been previously reported. Case Report. A 28-year-old woman developed pentobarbital-induced cardiopulmonary failure that was successfully treated with maximal medical management including arteriovenous extracorporeal membrane oxygenation. She made an ex...

The action of pentobarbital on primary afferents of the isolated frog spinal cord was analyzed with sucrose gap and intracellular recordings techniques. Pentobarbital in concentrations generally considered to be in the anesthetic range greatly prolonged presynaptic inhibition and also depolarized primary afferents. The depolarization was accompanied by an increase in excitability and resulted f...

Although a neurological examination is fundamental to the evaluation of comatose patients, it is less reliable in a medically induced coma. A commonly misinterpreted finding in patients in a pentobarbital coma is altered pupillary reactivity secondary to an exaggerated ciliospinal reflex. Recognizing an exaggerated ciliospinal reflex in patients in a pentobarbital coma is important and may prev...

Cypermethrin a widely used insecticide of Pyrethroids (type II) group, was administered in mice at two dose levels (1/10 of LD50 i.e. 2.5 mg/kg and 1/5 of LD50 i.e. 5.0 mg/kg) and pharmacodynamic interactions of insecticide were studied with centrally acting drugs viz. pentobarbital sodium, amphetamine, pentylenetetrazole, acepromazine and analgin. Cypermethrin pretreatment potentiated the acti...

Zusammenfassung Die humanmedizinische Anwendung von Barbituraten als Schlafmittel gilt heutzutage obsolet. Während Pentobarbital in Deutschland lediglich der Veterinärmedizin angewendet wird, nutzt man es aufgrund bei Überdosierungen schnell eintretenden Atemdepression z. B. Schweiz Freitodbegleitungen oder den USA Vollstreckung Todesstrafen. In ist Zugriff auf für unheilbar Kranke mit Wunsch z...

Mit Urteil 6B_646/2020 vom 9. Dezember 2021 hat das Bundesgericht entschieden, dass die Verschreibung von Natrium-Pentobarbital (NaP) für eine suizidwillige gesunde Person nicht nach Heilmittelgesetz, sondern den strengeren Regeln des Betäubungsmittelgesetzes zu beurteilen ist. Das zur Publikation in der amtlichen Sammlung vorgesehene Frage Zulässigkeit Suizidhilfe wegweisenden Charakter, lässt...

The effect of pentobarbital anesthesia upon the minimal voltage and current required for electrical ventricular defibrillation (the defibrillation threshold) was investigated in dogs. Threshold current, energy, and charge in five dogs averaged 2 per cent, 13 per cent, and 6 per cent less under surgical levels of pentobarbital anesthesia than thresholds in the same animals in the awake, unanesth...