(R)-(+)-Pulegone, a monoterpene constituent of pennyroyal oil, is a hepatotoxin that has been used in folklore medicine as an abortifacient despite its potential lethal effects. Pulegone is metabolized by human liver cytochrome P-450s to menthofuran, a proximate hepatotoxic metabolite of pulegone. Expressed human liver cytochrome (CYP) P-450s (1A2, 2A6, 2C9, 2C19, 2D6, 2E1, and 3A4) were tested...

Essential oils (EOs) are acclaimed for their antimicrobial properties, leading to multiple applications in various fields. In this work, four aromatic plants were used, namely thyme (Thymus mastichina L.), everlasting (Helychrysum stoechas Moench), European pennyroyal (Mentha pulegium L.) and fennel (Foeniculum vulgare Mill.). Hydrodistillation was the extraction method obtained extracts compos...

STATEMENT OF PROBLEM It is necessary to use irrigation solutions during cleaning and shaping of root canals to efficiently reduce the number of micro organisms. Sodium hypochlorite is used as an effective antibacterial endodontic irrigants. However, the extract of pennyroyal plant has also shown anti-bacterial characteristics comparable with antibacterial drugs. OBJECTIVES To compare the anti...

The flavoring of vinegars with aromatic fruits and medicinal herbs is a practice with increasing trend mostly in countries with oenological tradition, resulting in a product of improved quality and consumer attractiveness. This study was directed towards the evaluation of the impact of the maceration process on the volatile signature of wine-based aromatic vinegars (WBAVs). The evaluation was p...