The importance of cellular infiltrates in tissues has been investigated as a diagnostic tool, mechanism of pathogenesis, and prognostic indicator in certain human diseases. Eosinophils, in particular, have a distinct role in the development of cutaneous lesions in human autoimmune diseases. Identification of an eosinophilic infiltrate can aid the diagnosis of immunobullous disease in the early ...

Fogo Selvagem (FS) is an endemic form of pemphigus foliaceus (PF) which is prevalent in certain regions of Brazil (Diaz et al., 1989). Genetic and environmental factors such as insect bites may contribute to the development of FS (Aoki et al., 2004; Diaz et al., 1989; Moraes et al., 1997). Blister formation in FS is mediated by predominantly IgG4 antidesmoglein 1 (Dsg1) antibodies (Rock et al.,...

T he clinical features of pemphigus vulgaris (PV) are related to the presence and profile of antidesmoglein 3 (anti-dsg3) and antidesmoglein 1 (anti-dsg1) antibodies. Anti-dsg3 is associated with mucosal PV; the concurrent presence of anti-dsg3 and antidsg1, with mucocutaneous disease; and anti-dsg1 alone, with pemphigus foliaceus (PF). Shifts over time in the pattern of anti-dsg antibodies fro...

Pemphigus foliaceus is a benign variety of pemphigus group. It rare autoimmune blistering disease that affects the skin without mucosal involvement. can present in endemic and sporadic form; whereby form common Brazil Tunisia, known as fogo selvagem. There was no previous case reported Malaysia. We report 43-year-old man, who presented with generalized extensive blisters vesicles crust scale. T...

Pemphigus erythematosus (PE) is an autoimmune blistering disease combining features of pemphigus foliaceus (PF) and systemic lupus erythematosus (SLE). We report a case of PE associated with anti-double-stranded DNA (anti-dsDNA), anti-Smith (anti-Sm), anti-Ro (anti-SSA), and antiribonucleoprotein (anti-RNP) antibodies. This case required extensive immunosuppressive therapy. We treated our patie...

Endemic pemphigus foliaceus (EPF) is an autoimmune disease characterized by blister formation with a loss of cohesion and infiltration of inflammatory cells. We observed that supernatants of peripheral blood mononuclear cells from patients produced significantly more interleukin-1beta (IL-1beta) than those from stimulated healthy controls. Furthermore, a Th2 bias was observed in EPF patients wh...

Pemphigus is an autoimmune bullous disease observed with lesions in the skin and mucosa. Pemphigus is classified by antibodies against desmogleins, which is cadherin type intercellular adhesion factors involved in adhesion between epidermal cells. In this case, because erosion of the oral mucosa was the primary symptom, a relationship with membrane-dominant pemphigus vulgaris was strongly suspe...

The prototypic bullous skin diseases, pemphigus vulgaris, pemphigus foliaceus, and bullous pemphigoid, are characterized by the blister formation in the skin and/or oral mucosa in combination with circulating and deposited autoantibodies reactive with (hemi)desmosomes. Koch's postulates, adapted for autoimmune diseases, were applied on these skin diseases. It appears that all adapted Koch's pos...

OBJECTIVE Pemphigus is an acquired autoimmune blistering skin diseases, of which pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are two major subtypes. A novel commercial enzyme-linked immunosorbent assay (ELISA) against Dsg1 and Dsg3 has been well established for diagnosis and prediction of disease activity in PF and PV. At present, the benefit of anti-Dsg 1 and anti-Dsg 3 IgG by ELISA i...