SPIONs are composed of Fe3O4 or gamma Fe2O3 cores and a biocompatible shell from Dextran, PLA, PEG, Chitosan, PVA. have many important applications in medicine biology such as cell sorting, drug carrier, magnetic hyperthermia, resonance imaging (MRI). This study aims to check the ability copolymer PLA-PEG coated ferromagnetic nanosystems (Fe3O4@PLA-PEG) produced for MRI application. The results...

In this work, a novel protocol was developed for size tuning and cetyltrimethylammonium bromide (CTAB) removal of gold nanorods using commercially available nonionic fluorosurfactants (FSN), an excellent candidate for PEG and other modification reagents. The tunable gold nanorods can easily be obtained by stopping the ligand replacement reaction at different time intervals. The FSN-coated gold ...

The present study was undertaken to 1) formulate a pulsatile colonic delivery of simvastatin (SIM) as chronotherapy for treatment of hypercholesterolemia, and 2) enhance the dissolution profile of the prepared SIM chronotherapeutic system. Lipid based formulations were utilized to formulate SIM in capsule dosage form coated with Eudragit® S100. SIM was formulated using different percentages of ...

In this paper we demonstrate a procedure for preparing bacterial arrays that is fast, easy, and applicable in a standard molecular biology laboratory. Microcontact printing is used to deposit chemicals promoting bacterial adherence in predefined positions on glass surfaces coated with polymers known for their resistance to bacterial adhesion. Highly ordered arrays of immobilized bacteria were o...

BACKGROUND Gold nanoparticle toxicity research is currently leading towards the in vivo experiment. Most toxicology data show that the surface chemistry and physical dimensions of gold nanoparticles play an important role in toxicity. Here, we present the in vivo toxicity of 5, 10, 30, and 60 nm PEG-coated gold nanoparticles in mice. METHODS Animal survival, weight, hematology, morphology, or...

A continuous synthesis strategy enabling the large-scale and cost-effective functionalization of iron oxide nanoparticles in a single setup is developed, leading to fully biocompatible application-ready PEG coated nanoparticles.

Liposomal encapsulation is a useful drug delivery strategy for small molecules, especially chemotherapeutic agents such as doxorubicin. Doxil® is a doxorubicin-containing liposome ("dox-liposome") that passively targets drug to tumors while reducing side effects caused by free drug permeating and poisoning healthy tissues. Polyethylene glycol (PEG) is the hydrophilic coating of Doxil® that prot...

Microspheres made of poly(lactic-co-glycolic acid) (PLGA) are biocompatible and biodegradable, rendering them a promising tool in the context of drug delivery. However, nonspecific adsorption of plasma proteins on PLGA micro- and nanospheres is a main limitation of drug targeting. Poly(L-lysine)-g-poly(ethylene glycol) (PLL-g-PEG), physisorbed on flat metal oxide surfaces, has previously been s...

The objective of this study was to optimize the physicodynamic conditions of polymeric system as a coating substrate for drug eluting stents against restenosis. As Nitric Oxide (NO) has multifunctional activities, such as regulating blood flow and pressure, and influencing thrombus formation, a continuous and spatiotemporal delivery of NO loaded in the polymer based nanoparticles could be a via...