Salmeterol is a new inhaled beta 2 adrenoceptor agonist, which has been shown in animal experiments to produce a more prolonged bronchodilator effect than currently available beta 2 adrenoceptor agonists. It was studied in eight adult asthmatic patients. Each patient received on separate test days salbutamol 200 micrograms and salmeterol 50, 100, and 200 micrograms according to a randomised, do...

BACKGROUND The efficacy of dry powder inhalers depends on the patient's inspiratory flow. Drug delivery from the Turbohaler (Turbuhaler in some countries), a multidose powder inhaler, is optimal at flows of > 40 l/min. The aim of this study was to investigate the peak inspiratory flow that can be generated by asthmatic patients through the budesonide Turbohaler (PIFTBH) during maintenance treat...

The aim of our study was to verify if the type of nebulizer used could influence the results of aerosol therapy with beclomethasone dipropionate (BDP) in mild allergic asthma. We assigned 27 asthmatics allergic to grasses to 3 groups and treated them from May to July 1998 with aerosol therapy with BDP (800 microg) b. i. d. via nebulizer + pMDI salbutamol (200 microg) if necessary. Each group us...

printing supported by . Visit Chiesi at Stand B2.10 SUNDAY, SEPTEMBER 2ND 2012 Pulmonary inflammation and levels of immunoregulatory cytokines were determined in BAL. Total serum IgE was measured in blood. The analyzes were made on days 2, 4 and 7 after induction of asthma. Results: Animals sensitized to persulfate salts showed an increase in bronchial hyperresponsiveness to methacholine and in...

BACKGROUND Peak forced expiratory flow (PEF) and FEV(1) are spirometry measures used in diagnosing and monitoring lung diseases. We tested the premise that within-test variability in PEF is associated with corresponding variability in FEV(1) during a single test session. METHODS A total of 2,464 healthy adults from the Health, Aging, and Body Composition Study whose spirometry results met Ame...

BACKGROUND Daily changes in ambient concentrations of particulate matter, nitrogen oxides and ozone are associated with increased cardiopulmonary morbidity and mortality, with the lungs and their function being a vulnerable target. METHODS To evaluate the association between daily changes in air pollution and lung function in healthy adults we obtained annual lung function measurements from a...

S OF TALKS PRESENTED AT THE INTERNATIONALMATHEMATICAL CONFERENCE TOPICS IN MATHEMATICAL ANALYSISAND GRAPH THEORY (MAGT) A Satellite Meeting to ICM 2006 BELGRADE, SERBIA, SEPTEMBER 1–4, 2006. Editorial note. Selected peer-refereed full presented at MAGT 2006, are publishedin: Applicable Analysis and Discrete Mathematics, 1, No. 1 (2007).

The aim of this study was to evaluate the role of ageing on variability of airflow obstruction and on the specific pattern of nocturnal exacerbations ("morning dipping" of peak expiratory flow (PEF)) in asthma. Two groups of stable asthmatics (Group A: 23 patients, aged 14-47 yrs; Group B: 20 patients, aged 53-74 yrs), that were similar for duration of disease, degree of obstruction and respons...