Brain tumor incidence is on the rise, and glioblastoma comprises majority of primary tumors. Despite maximal safe resection adjuvant chemoradiation, median survival for high-grade glioma remains poor. For this reason, it important to develop incorporate new treatment strategies. Oncolytic virotherapy has emerged as a viable therapeutic entity fill gap. Preclinical research shown oncolytic be ro...

BACKGROUND Cultured brain tumors can form neurospheres harboring tumorigenic cells with self renewal and differentiation capacities. Renewable neurosphere formation has clinical predictive value in adult malignant gliomas, yet its prognostic role for pediatric brain tumors is unknown. METHODS Established neurosphere conditions were used for culturing samples from glial, embryonal and mixed gl...

OBJECTIVE Research on the long-term sequelae of treatment for pediatric brain tumors has identified significant neurocognitive deficits experienced by many survivors. Despite indications of deficits based on cognitive assessment, the identification of specific neurobiological mechanisms of these deficits using neuroimaging techniques has yet to be considered. METHOD This study used norm-refer...

BACKGROUND AND PURPOSE The pattern of contrast leakage from DSC tissue signal intensity time curves have shown utility in distinguishing adult brain neoplasms, but has limited description in the literature for pediatric brain tumors. The purpose of this study is to evaluate the utility of grading pediatric brain tumors with this technique. MATERIALS AND METHODS A retrospective review of tissu...

BACKGROUND Primitive brain tumors are the leading cause of cancer-related death in children. Tumor cells with stem-like properties (TSCs), thought to account for tumorigenesis and therapeutic resistance, have been isolated from high-grade gliomas in adults. Whether TSCs are a common component of pediatric brain tumors and are of clinical relevance remains to be determined. METHODOLOGY/PRINCIP...

background : central nervous system tumors account for 2%-5% of all malignancies in humans. these tumors account for 2% of all pediatric cancers. the worldwide incidence of primary central nervous system tumors is estimated at 3.9 (males) and 3.2 (females) per 100000 person-years. the incidence of brain tumor cases has been reported as 3.67% of all malignancies and 4% of all cancer mortalities ...