SUMMARY Reconstructive surgeons supporting military operations are required to definitively treat severe pediatric abdominal injuries in austere environments. The safety and efficacy of using a components separation technique to treat large ventral hernias in pediatric patients in this setting remains understudied. Components separation technique was required to achieve definitive closure in a ...

The cytofluorometric analysis of dissociated tumor samples identified distinct immunophenotypes among the most common variants of pediatric brain tumor. These findings suggest that immunotherapeutic regimens against pediatric brain malignancies should be tailored to individual tumor types.

Case 1 A 15-month old girl presented with frequent vomiting and fever 6 hours before admission. Physical examination revealed no jaundice. There was a palpable mass of cystic consistency at left abdomen. Plain abdomen showed ill-defined mass lesion at mid and left upper abdomen (fig.1) CT was done from other medical center before admission and showed a large well-defined cystic mass clearly sep...

Hodgkin lymphoma (HL) is a lymphoid malignancy that is typically derived from germinal-center B cells. EBV infection, mutations in NF-κB pathway genes, and genetic susceptibility are known risk factors for developing HL. CD30 and NF-κB have been identified as potential biomarkers in pediatric HL patients, and these molecules may represent therapeutic targets. Although current risk adapted and r...

Blunt pediatric trauma is a major threat to the health and well-being of children. Nationwide, many practitioners care for children who face this issue. Some key principles related to the evaluation and management of these children are elucidated in this article.

Sarcomas are malignant tumors of mesenchymal origin. They comprise < 1% adult malignancies and about 15-20% pediatric malignancies. These subdivided into bone cartilage sarcomas soft tissue type. the maxillofacial region 5-10% all this part body. Usually do not originate from benign tumors. Among factors known to induce sarcoma growth are: genetic defects, exposure pesticides herbicides, ionizi...

BACKGROUND Concerns have been raised about a potential link between the use of TNF inhibitors and development of malignancy in the pediatric population. We examined the worldwide experience of etanercept use in pediatric patients and the occurrence of malignancies as reported from clinical trials, registry studies, post-marketing surveillance, and published scientific literature. METHODS All ...

The rationale for combining surgery, radiotherapy and chemotherapy is discussed and the clinical results seen with surgery and adjuvant radiochemotherapy in three major abdominal malignancies are reviewed. A systematic approach to the literature was used. In rectal cancer, postoperative radiochemotherapy is an established treatment, although there is weak scientific support for the combined app...