Although targeted delivery mediated by ligand modified or tumor microenvironment sensitive nanocarriers has been extensively pursued for cancer chemotherapy, the efficiency is still limited by premature drug release after systemic administration. Herein we report a highly blood-stable, tumor-adaptable drug carrier made of disulfide (DS) bonded mPEG-(Cys)(4)-PDLLA micelles. Intravenously injecte...

Biodegradable nanoarchitectures, with well-defined morphological features, are of great importance for nanomedical research; however, understanding (and thereby engineering) their formation is a substantial challenge. Herein, we uncover the supramolecular potential of PEG-PDLLA copolymers by exploring the physicochemical determinants that result in the transformation of spherical polymersomes i...

Cell pyroptosis has a reciprocal relationship with various cancer treatment modalities such as chemotherapy. However, the tumor microenvironment, characterized by hypoxia, substantially restricts development and application of therapies that integrate cell pyroptosis. Therefore, cascade amplification oxidative stress interfering redox homeostasis in tumors may be promising approach. In this stu...

OBJECTIVES The aim of this study was to examine which component of drug-eluting stents (DES) plays a major role in enhanced coronary vasoconstricting responses after DES implantation in pigs. BACKGROUND Recent studies have reported unremitting angina due to vasomotion abnormalities even after successful DES implantation. However, it remains to be elucidated which component of DES (metal stent...

Background: Platelet-rich plasma (PRP) is blood containing an above baseline level of platelets and growth factors. Recently, has come to the attention aesthetic surgeons, with burgeoning new applications ranging from hair restoration soft tissue augmentation. Injectable Poly-D,L-Lactic Acid (PDLLA) a biostimulator rather than traditional filler, which provides immediate volumetric improvement....

The in vitro assessments suggested the essential features for bio screws applications. effects of bioactive glass nanoparticles (BG) during studies poly (D/L) lactide (PDLLA)/polycaprolactone (PCL)/BG nanocomposites (PPB) were assessed. PDLLA/PCL (PP) blends chosen as control groups. Apatite formations capabilities, weight and pH variations, alkaline phosphatase activity (ALP), MTT assay assign...

Various ratios PEOz-PDLLA diblock copolymers were synthesized through ring-opening polymerization of DL-lactide initiated by monohydroxyl terminated poly(2-ethyl-2-oxazoline) (PEOz-OH). The chemical composition and molar mass the resulting determined using NMR GPC. Spherical micelles with a diameter from 104 to 136 nm obtained via self-assembly in water, as evidenced TEM DLS. CMC was well below...

Pseudomonas aeruginosa and Staphylococcus aureus are commonly associated with hospital-acquired infections and are known to form biofilms. Ciprofloxacin (CIP), which is normally used to treat these infections, is seldom effective in killing cells in a biofilm. This is mostly due to slow or weak penetration of CIP to the core of biofilms. The problem is accentuated by the release of CIP below MI...