نتایج جستجو برای: pdgfr β

تعداد نتایج: 178428  

Journal: :American journal of physiology. Cell physiology 2016
Abdo J Najy Gregory Dyson Bhanu P Jena Chen-Yong Lin Hyeong-Reh C Kim

Activation of β-platelet-derived growth factor receptor (β-PDGFR) is associated with prostate cancer (PCa) progression and recurrence after prostatectomy. Analysis of the β-PDGFR ligands in PCa revealed association between PDGF-D expression and Gleason score as well as tumor stage. During the course of studying the functional consequences of PDGF ligand-specific β-PDGFR signaling in PCa, we dis...

Journal: :The Journal of biological chemistry 2011
Alexia Eliades Nikolaos Papadantonakis Ajoy Bhupatiraju Kelley A Burridge Hillary A Johnston-Cox Anna Rita Migliaccio John D Crispino Hector A Lucero Philip C Trackman Katya Ravid

Lysyl oxidase (LOX), a matrix cross-linking protein, is known to be selectively expressed and to enhance a fibrotic phenotype. A recent study of ours showed that LOX oxidizes the PDGF receptor-β (PDGFR-β), leading to amplified downstream signaling. Here, we examined the expression and functions of LOX in megakaryocytes (MKs), the platelet precursors. Cells committed to the MK lineage undergo mi...

Journal: :American journal of physiology. Cell physiology 2013
Takashi Kohno Norifumi Urao Takashi Ashino Varadarajan Sudhahar Hyoe Inomata Minako Yamaoka-Tojo Ronald D McKinney Tohru Fukai Masuko Ushio-Fukai

Platelet-derived growth factor (PDGF) stimulates vascular smooth muscle cell (VSMC) migration and neointimal formation in response to injury. We previously identified IQ-domain GTPase-activating protein 1 (IQGAP1) as a novel VEGF receptor 2 binding scaffold protein involved in endothelial migration. However, its role in VSMC migration and neointimal formation in vivo is unknown. Here we show th...

Journal: :International journal of clinical and experimental pathology 2014
Sang Hoon Song In Gab Jeong Dalsan You Jun Hyuk Hong Bumsik Hong Cheryn Song Woon Yong Jung Young Mee Cho Hanjong Ahn Choung-Soo Kim

PURPOSE We aimed to investigate the correlations between the expression of VEGF, PDGF-B, and their receptors (VEGFR2 and PDGFR-β) with pathologic stage or cell type in non-metastatic renal cell carcinoma. MATERIALS AND METHODS VEGF, VEGFR2, PDGF-B, and PDGFR-β protein expression were evaluated immunohistochemically in prospectively collected 1,423 tumour samples obtained during radical or par...

Fatemeh Jalalvand Kazem Parivar Parichehreh Yaghmaei,

Background Imatinib mesylate, a small-molecular analog of adenosine triphosphate (ATP) that potently inhibits tyrosine kinase activities of Bcr–Abl, PDGFR-β, PDGFR-α, c-Fms, Arg and c-kit, is one of the novel molecularly targeted drugs being introduced into cancer therapy. We tested the effect of imatinib on the ovarian histological structure and the concentration of estrogen and progesterone, ...

2018
Rie Nishishita Satoko Morohashi Hiroko Seino Yunyan Wu Tadashi Yoshizawa Toshihiro Haga Kensuke Saito Kenichi Hakamada Shinsaku Fukuda Hiroshi Kijima

Colorectal cancer is one of the most common causes of mortality from cancer worldwide. Previous studies have demonstrated that cancer-associated fibroblasts (CAFs) promote neoangiogenesis and tumor growth for various tumors. The present study analyzed CAF markers, including α-smooth muscle actin (α-SMA), collagen I, platelet-derived growth factor receptor-β (PDGFR-β), and D2-40 (antibody recogn...

Journal: :Investigative ophthalmology & visual science 2017
Kei Takahashi Masamitsu Shimazawa Hiroshi Izawa Yuki Inoue Yoshiki Kuse Hideaki Hara

Purpose Platelet-derived growth factor (PDGF)-BB is known to have neuroprotective effects against various neurodegenerative disorders. The purpose of this study was to determine whether PDGF-BB can be neuroprotective against light-induced photoreceptor damage in mice. Methods Mice were exposed to 8000-lux luminance for 3 hours to induce phototoxicity. Two hours before light exposure, the expe...

Journal: :International journal of clinical and experimental pathology 2014
Si-Ming Yuan Yao Guo Xiao-Jun Zhou Wei-Min Shen Hai-Ni Chen

Infantile hemangioma, a common benign tumor of infancy, grows quickly in the first year of life, and then regresses slowly to fibrofatty tissue in childhood. The accumulation of fibrofatty tissue in hemangioma involution indicates adipogenesis during this period. Perivascular cells (PCs) from multiple organs display multi-lineage differentiation, including adipogenesis. So we supposed that PCs ...

2016
Hidehiko Takigawa Yasuhiko Kitadai Kei Shinagawa Ryo Yuge Yukihito Higashi Shinji Tanaka Wataru Yasui Kazuaki Chayama

Interaction between tumor cells and stromal cells plays an important role in the growth and metastasis of colon cancer. We previously found that carcinoma-associated fibroblasts (CAFs) expressed platelet-derived growth factor receptor-β (PDGFR-β) and that PDGFR targeted therapy using imatinib or nilotinib inhibited stromal reaction. Bone marrow-derived mesenchymal stem cells (MSCs) migrate to t...

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