Striatal dopamine depletion is a key pathophysiological feature of Parkinson's disease (PD) causing motor and nonmotor symptoms. Research on nonmotor symptoms has mainly focused on frontostriatal functions. However, dopamine pathways ascending from the ventral tegmental area also innervate hippocampal structures and modulate hippocampal-dependent functions, such as spatial memory. Using a virtu...

Background Anti-PD1/PD-L1 monoclonal antibodies (mAbs) increase overall survival compared to standard of care (SOC) in different tumors. However, a proportion of patients (pts) will have progressive disease (PD) as best response. We conducted a meta-analysis to study the rates of response comparing these antibodies with SOC. Methods A search of published trials in MEDLINE and EMBASE analyzing...

PURPOSE To determine the influence of the spatial extent and the depth of localized field loss on the computation of the General Height (GH) method for estimating the diffuse component of visual field loss and, therefore, on the subsequent appearance of the Pattern Deviation (PD) map. METHODS Varying shapes and depths of localized glaucomatous field loss were modeled in each of 82 Humphrey Fi...

Complexity of multifactorial diseases as Parkinson's disease (PD) often complicate identifying causal genetic factors by traditional approaches such as positional cloning and candidate gene analyses. PD is etiologically and genetically complex disease and second most common neurodegenerative disorder after Alzheimer's disease. The most cases of PD are idiopathic and small growing subset of indi...

Introduction: The significance of tumor budding and programmed death ligand 1 (PD-L1) has not been established in gastric adenocarcinoma (GAC). Objectives: This study evaluated PD-L1 expression with regard to microenvironment, clinicopathologic parameters, overall survival GAC. Patients Methods: Totally, 102 GAC cases were assessed immunohistochemically. associations features, tumor-infiltratin...

Partial discharge (PD) in electrical equipment is one of the major causes of electrical insulation failures. Fast and accurate positioning of PD sources allows timely elimination of insulation faults. In order to improve the accuracy of PD detection, this paper mainly studies the direction of arrival (DOA) estimation of PD ultrasonic signals based on a step-by-step over-complete dictionary. The...

Voltage-gated sodium, potassium, and calcium channels are made of a pore domain (PD) controlled by four voltage-sensing domains (VSDs). The PD contains the ion permeation pathway and the activation gate located on the intracellular side of the membrane. A large number of small molecules are known to inhibit the PD by acting as open channel blockers. The voltage-gated proton channel Hv1 is made ...

In this paper a method for extracting Partial Discharge (PD) signals is introduced, which is implemented for evaluating electrical measured partial discharges on a 66 kV / 25 MVA fully interleaved winding of a power transformer. Applying wavelet transform to a signal produces a wavelet detail coefficient distribution throughout the time-scale, which depends on the mother wavelet chosen. This me...

Alkaline fuel cells (AFCs) are relevant for niche applications, but still require enhanced performance and lifetime. Active durable hydrogen oxidation reaction (HOR) catalysts must be developed: linking their electrochemical surface area (ECSA) loss to HOR activity understanding whether the ECSA of carbon-supported platinum group metal-based (PGM/C) is irreversible (nanoparticles dissolution, d...

Between November 2009 and September 2011, 12 patients (6 women, 6 men) undergoing continuous peritoneal dialysis (PD) or automated PD developed puncture-like holes in the PD catheter near the interface of the adapter with the superior aspect of the Silastic PD catheter The adapter is used to connect the PD catheter to the PD transfer set. Over the course of 23 months, the 12 patients presented ...