OBJECTIVES To determine the distribution of HLA-DR type and FcgammaRIIa/IIIa polymorphisms, and to analyse the combined effects of these genes for susceptibility in Korean systemic lupus erythematosus (SLE) patients. METHODS A total of 299 SLE patients meeting 1982 ACR criteria and 144 Korean disease-free controls were enrolled. Genotyping for the FcgammaRIIa 131 R/H and FcgammaRIIIa 176 F/V ...

BACKGROUND There are 3 classes of HLA molecules; HLA class I, II and III, of which different classes have different functions. HLA-B gene which belongs to HLA class I play an important role predicting drug hypersensitivity. MATERIALS AND METHODS Nine hundred and eighty-six Thai subjects who registered at a pharmacogenomics laboratory were determined for HLA-B genotype using a two-stage sequen...

Context: Non-fatal injuries represent a public health issue. Among them, lower limb fractures have large impact on the costs related to orthopedic treatments. In this work, three-dimensional reconstruction of tibia and fibula was performed for biomechanical applications with purpose defining 3D parameters that allow reducing patients’ radiation exposure computational costs. Method: For reconstr...

Kerupuk Ikan Sarden dari UMKM Dahlia di Desa Air Itam Kecamatan Jejawi Kabupaten Ogan Komering Ilir, Sumatera Selatan sudah dikenal dan digemari sebagai produk unggulan daerah yang sangat potensial untuk dikembangkan. Tujuan pengabdian ini adalah memperbaiki aspek sanitasi higienis, melalui perbaikan layout ruang produksi sesuai dengan syarat SSOP (Sanitation Standard Operating Procedure) GMP (...

In yeast, assembly of exocytic soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor (SNARE) complexes between the secretory vesicle SNARE Sncp and the plasma membrane SNAREs Ssop and Sec9p occurs at a late stage of the exocytic reaction. Mutations that block either secretory vesicle delivery or tethering prevent SNARE complex assembly and the localization of Sec1p...

BACKGROUND The human leukocyte antigen (HLA) system is widely used as a strategy in the search for the etiology of renal function impairment. OBJECTIVES This study was carried out to detect the most common HLA alleles' distribution in kidney transplant in both donors and recipients, and clarify the association between HLA alleles and renal dysfunction immediately after transplantation. PATI...

Previously, we have reported the results of our retrospective study on the effect of HLA class II allele matching on the outcome of corneal transplant. Here, we demonstrate our findings of the study for HLA class I allele matching in the same study subjects. Eighty transplant recipients were typed for HLA-A, and 79 transplant recipients were typed for HLA-B alleles, by PCR-SSOP. The association...