BACKGROUND To determine the level of plasma homocysteine in patients with polycystic ovary syndrome (PCOS) compared with healthy controls. MATERIALS AND METHODS In this prospective case-control study on 85 PCOS women and 83 controls matched by body mass index (BMI), homocysteine levels were assessed. RESULTS The mean level of homocysteine was 16.25 ± 11.94 μmol/L in patients with PCOS and 1...

Background: Trinucleotide repeats CAG (n) in androgen receptor gene is thought to be central to PCOS genetic susceptibility. However, previous studies of PCOS have shown variable association of CAG (n) polymorphism with PCOS. Objective: To assess the association of the AR gene CAG repeat length polymorphism with PCOS among Egyption patients, and its influence on clinical and biochemical androge...

BACKGROUND It is reasonable to think that some biochemical characteristics of follicular fluid (FF) surrounding the oocyte may play a critical role in determining the quality of oocyte and the subsequent potential needed to achieve fertilization and embryo development. OBJECTIVE This study was carried out to evaluate the levels of FF homocysteine (Hcy) in IVF candidate polycystic ovary syndro...

INTRODUCTION There are still not enough data showing whether patients with idiopathic hirsutism (IH) also have insulin resistance. The association between polycystic ovary syndrome (PCOS) and insulin resistance is well documented in the literature, but the Rotterdam Consensus has concluded that principally obese women with PCOS should be screened for the metabolic syndrome. We intended to inves...

Polycystic Ovary Syndrome (PCOS) is a common endocrine-reproductive disease in females. PCOS patients show decreased ovary granular cells, which is possibly related with cell apoptosis. This study thus aimed to investigate the apoptotic mechanism in PCOS via measuring the protein expressions of apoptosis and anti-apoptosis related molecules in PCOS patients. A total of 30 PCOS patients were rec...

Vitamin D deficiency (VDD) is common in women with and without polycystic ovary syndrome (PCOS) and may be associated with metabolic and endocrine disorders in PCOS. The aim of this meta-analysis is to assess the associations of serum vitamin D levels with metabolic and endocrine dysregulations in women with PCOS, and to determine effects of vitamin D supplementation on metabolic and hormonal f...

The purpose of this study was to investigate the impact of body mass index (BMI) on the outcomes of IVF/ICSI treatment cycles in Chinese patients with polycystic ovary syndrome (PCOS). Women with PCOS (n = 128) and tubal factor (n = 128) underwent a conventional long GnRH agonist suppressive protocol. Women with PCOS had significantly more oocytes retrieved (P < 0.05) and available embryos (P <...

OBJECTIVE To evaluate in vitro maturation (IVM) in sub-fertile women with polycystic ovarian syndrome (PCOS) undergoing in vitro fertilisation (IVF), by comparing outcomes with a control group of non-PCOS. STUDY DESIGN A search strategy was developed for PubMed and studies reporting rates of the following outcomes (live birth; clinical pregnancy; implantation; cycle cancellation; oocyte matur...

BACKGROUND Lipocalin-2 is a novel adipokine that appears to play a role in the development of insulin resistance. Serum lipocalin-2 levels are elevated in obese patients. Obesity and insulin resistance are cardinal characteristics of the polycystic ovary syndrome (PCOS). However, there are limited data on serum lipocalin-2 levels in patients with PCOS. The aim of the present study was to assess...

BACKGROUND Polycystic ovary syndrome (PCOS) is associated with an increased cardiovascular disease (CVD) risk and early atherosclerosis. Epicardial adipose tissue thickness (EATT) is clinically related to subclinical atherosclerosis. In the present study, considering the major role of neutrophil gelatinase-associated lipocalin (NGAL) which is an acute phase protein rapidly releasing upon inflam...