Phase change memory (PCM) is an emerging memory technology with many attractive features: it is non-volatile, byte-addressable, 2–4X denser than DRAM, and orders of magnitude better than NAND Flash in read latency, write latency, and write endurance. In the near future, PCM is expected to become a common component of the memory/storage hierarchy for a wide range of computer systems. In this pap...

In recent years, the energy consumption of computing systems has increased and a large fraction of this energy is consumed in main memory. Towards this, researchers have proposed use of non-volatile memory, such as phase change memory (PCM), which has low read latency and power; and nearly zero leakage power. However, the write latency and power of PCM are very high and this, along with limited...

Pseudomonas cepacia has recently emerged as an important pathogen affecting cystic fibrosis (CF) patients. We evaluated three selective media to assess their comparative potential for identification of patients colonized with P. cepacia and for efficacy of detection of P. cepacia in environmental fluids. Test organisms included P. cepacia isolates from CF patients (10 each from two CF centers),...

INTRODUCTION: Structure and composition of articular cartilage as well as metabolic activity of chondrocytes (cartilage cells) change in osteoarthritis (OA) [1]. Among these changes, cell volume has been reported to increase [1,2]. Furthermore, the structure, composition and mechanical properties of the pericellular matrix (PCM) alter in OA [3]. However, the role of PCM in modulating volumetric...

Three hundred and fifty-two patients with alcoholic hepatitis were evaluated for protein-calorie malnutrition (PCM). In order to facilitate data analysis of nutritional status, a PCM score was calculated for each patient using eight nutritional parameters. The PCM score correlated significantly with mortality, clinical severity of the liver disease, and biochemical liver dysfunction. When 30 da...

The pericellular matrix (PCM) is a narrow region that is rich in type VI collagen that surrounds each chondrocyte within the extracellular matrix (ECM) of articular cartilage. Previous studies have demonstrated that the chondrocyte micromechanical environment depends on the relative properties of the chondrocyte, its PCM and the ECM. The objective of this study was to measure the influence of t...

Phase change memory (PCM) is a promising memory technology that can offer higher memory capacity than DRAM. Unfortunately, PCM’s access latencies and energies are higher than DRAM and its endurance is lower. DRAM-PCM hybrid memory systems use DRAM as a cache to PCM, to achieve the low access latencies and energies, and high endurance of DRAM, while taking advantage of the large PCM capacity. A ...

BACKGROUND centrosomes are major microtubule organizing centers in animal cells, and they comprise a pair of centrioles surrounded by an amorphous pericentriolar material (PCM). Centrosome size is tightly regulated during the cell cycle, and it has recently been shown that the two centrosomes in certain stem cells are often asymmetric in size. There is compelling evidence that centrioles influe...

Phase change memory (PCM) is a promising alternative to DRAM, though its high latency and energy costs prohibit its adoption as a drop-in DRAM replacement. Hybrid memory systems comprising DRAM and PCM attempt to achieve the low access latencies of DRAM at the large capacities of PCM. However, known solutions neglect to assess the utility of data placed in DRAM, and hence fail to achieve high p...

We identified Xenopus pericentriolar material-1 (PCM-1), which had been reported to constitute pericentriolar material, cloned its cDNA, and generated a specific pAb against this molecule. Immunolabeling revealed that PCM-1 was not a pericentriolar material protein, but a specific component of centriolar satellites, morphologically characterized as electrondense granules, z 70–100 nm in diamete...