Changes in endothelial glycocalyx are one of the earliest changes in development of cardiovascular disease. The endothelial glycocalyx is both an important biological modifier of interactions between flowing blood and the vessel wall, and a determinant of organ perfusion. We hypothesize that deeper penetration of erythrocytes into the glycocalyx is associated with reduced microvascular perfusio...

Intrarenal distribution and function(s) of the peripheral benzodiazepine receptor (PBR) remain uncertain. The goals of this study were to (1) develop a specific anti-rat PBR antibody and (2) map intrarenal immunoreactive PBR (irPBR) in untreated rats and in rats that received chronic angiotensin II infusion (200 ng/kg per min, subcutaneously, 17 d). A polyclonal rabbit antibody was raised again...

Regularization is a technique widely used to improve the stability of solutions to statistical problems. We propose a new regularization concept, performance-based regularization (PBR), for data-driven stochastic optimization. The goal is to improve upon Sample Average Approximation (SAA) in finite-sample performance while maintaining minimal assumptions about the data. We apply PBR to mean-CVa...

We propose a plasmonic Bragg reflector (PBR) composed of a single-layer graphene-based silicon grating and numerically study its performance. An external voltage gating has been applied to graphene to tune its optical conductivity. It is demonstrated that SPP modes on graphene exhibit a stopband around the Bragg wavelengths. By introducing a nano-cavity into the PBR, a defect resonance mode is ...

A cache replacement algorithm called probability based replacement (PBR) is proposed in this paper. The algorithm makes replacement decision based on the byte access probabilities of documents. This concept can be applied to both small conventional web documents and large video documents. The performance of PBR algorithm is studied by both analysis and simulation. By comparing cache hit probabi...

Peripheral-type benzodiazepine receptor (PBR) and central-type benzodiazepine receptor (CBR) in salivary gland play a role in the inhibitory regulation of salivary secretion in rodents. Diazepam-binding inhibitor (DBI), an endogenous ligand for PBR, produces neurosteroids, which modulate CBR activity. In this study, we investigated the effect of repetitive administration of diazepam (DZP) on sa...

This paper describes an experimental comparison of two reading techniques, namely Checklist-based reading (CBR) and Perspective-based reading (PBR) for Object-Oriented (OO) design inspection. Software inspection is an effective approach to detect defects in the early stages of the software development process. However, inspections are usually applied for defect detection in software requirement...

We consider a shared store based on distributed shared memory (DSM), supporting persistence by reachability (PBR), a very simple data sharing model for a distributed system. This DSM+PBR model is based on distributed garbage collection (GC). Within a general model for DSM+PBR, we specify a distributed GC algorithm that is efficient and scalable. Its main features are: (i) independent collection...

Planning by Rewriting (PbR) is a paradigm for efficient high-quality planning that exploits declarative plan rewriting rules and efficient local search techniques to transform an easy-to-generate, but possibly suboptimal, initial plan into a high-quality plan. In addition to addressing planning efficiency and plan quality, PbR offers a new anytime planning algorithm. The plan rewriting rules ca...

The 3D structure of the 18-kDa transmembrane (TM) protein TSPO (translocator protein)/PBR (peripheral benzodiazepine receptor), which contains a binding site for benzodiazepines, is important to better understand its function and regulation by endogenous and synthetic ligands. We have recently determined the structure of mammalian TSPO/PBR in complex with the diagnostic ligand PK11195 [1-(2-chl...