Introduction: Spinal cord injuries (SCI) lead to permanent irreversible functional deficits.  Poor prognosis of patients is the motivation of searching a treatment for the chronic injury.  Planting stem cells provides us with a promising strategy. In the meanwhile, the use of olfactory ensheathing cells (OECs) has shown very good results.  This study aims at evaluating the effe...

objective: to determine the effects of recombinant human erythropoietin (rhepo) on functional outcome and disability of patients with traumatic cervical spinal cord injury (sci).  methods: this was a randomized, double blind, placebo controlled clinical trial being performed in nemazee and shahid rajaei hospitals of shiraz during a 3-year period from 2011 to 2014. a total number of 20 patients ...

bone marrow mesenchymal stem cells can differentiate into neurons and astrocytes after transplantation in the spinal cord injury of rats. although bone marrow mesenchymal stem cells are known to protect against spinal cord injury through anti-apoptotic effects, but generation of neural stem cells with large number and safety protocols unclear. in the present study, described the differentiation...

background and aim: the normal response of h-reflex depression (hd) was reduced in chronic spinal cord injury (sci) patients. the reduction of this normal response can lead to increase the muscle tone and spasticity. the purpose of this study is to investigate the effect of tripolar cathodal stimulation on hd in sci patients.   materials and methods: this study was conducted in 10 volunteered s...

A major problem for neuroscientists and clinicians is why the central nervous system shows ineffective regeneration after injury. Injured peripheral nerve fibers reform their connections, whereas those in injured spinal cord never re-grow. Insights into the mechanisms for repair and restoration of function after spinal cord injury have been obtained by experiments showing that injured nerve cel...

Background & Aim: Spinal cord injury (SCI) has a very long history, and its cases form a large proportion of patients admitted to trauma centers in Iran. Studies show that repair after spinal cord injury can be done. In fact, many pharmaceutical agents, such as erythropoietin (EPO), are applied to reduce secondary injury following the initial disorder and to maintain the nerve tissue. Methods &...

Objectives: Nowadays, spinal cord lesions, specially its injury, is one of the diseases/injuries that human-being is been affected by. It not only causes irreversible economical/social/cultural problems & uncompensated costs to the patient’s family & society but also, makes active peoples to inactive & needy ones. Till now, there is no successful treatment for these patients so this ailment, it...

Background: Following spinal cord injury, reactive astrocytes upregulate chondroitin sulfate proteoglycans (CSPGs) which act as a barrier to neuronal repair and regeneration. Therefore, enzymatic digestion of CSPGs by chondroitinase ABC (cABC) is a key strategy in the treatment of spinal cord injury. Furthermore, cABC has been shown to attenuate post spinal cord injury inflamma...

conclusions the results indicate that a decrease in health status level of veterans, physically and mentally, can affect the health-related qol of their caregiving spouses. results the mean age and standard deviation of veterans and their spouses were 48.5 ± 5.9 and 44.8 ± 7.2, respectively and their number of children ranged between 0-6. our data analysis showed that there was a significant di...

A major problem for neuroscientists and clinicians is why the central nervous system shows ineffective regeneration after injury. Injured peripheral nerve fibers reform their connections, whereas those in injured spinal cord never re-grow. Insights into the mechanisms for repair and restoration of function after spinal cord injury have been obtained by experiments showing that injured nerve cel...