BACKGROUND Evaluation of myocardial function is clinically challenging in dogs with degenerative mitral valve disease (DMVD). Although myocardial dysfunction is caused by pathologic degeneration, histopathologic progression is poorly understood. OBJECTIVES To characterize myocardial and pulmonary pathologic changes according to severity in dogs with naturally occurring DMVD, and to investigat...

PURPOSE To determine the effects of intravitreal anti-vascular endothelial growth factor (VEGF) on thickness of the retinal nerve fiber layer (RNFL) in patients with age-related macular degeneration. METHODS Twenty eyes of 20 patients diagnosed with age-related macular degeneration who underwent intravitreal anti-VEGF injection were studied. Postinjection RNFL thickness was measured using opt...

The tracheas of 12 patients who had undergone autopsies after percutaneous dilatational tracheotomy (PDT) were analyzed macroscopically and microscopically. The puncture site of the trachea varied from just below the cricoid cartilage (two patients) to below the third ring (three patients). A fracture of one or more tracheal rings was present in 11 patients, of whom 2 had a fractured cricoid. D...

BACKGROUND Although essential tremor (ET) is one of the most common neurologic disorders, there have been few postmortem studies. We recently reported postmortem changes (torpedoes and Bergmann gliosis) in the cerebellar cortex in a few ET cases. OBJECTIVE To describe more extensive postmortem changes in the cerebellum in another ET case. DESIGN Case report. RESULTS A 90-year-old woman ha...

Background: Lung cancer (LC) is a global public health priority. In this study, the epidemiology and current trends of primary LCs were investigated in northeast of Iran.    Methods: Demographic and pathologic records of primary LCs during 1985-2012 in Mashhad (capital of northeast of Iran) were reviewed. Data were obtained from archives of the largest referral oncologic hospital and the only ...

Dramatic improvements in survival for children with cancer have led to increased numbers of posttreatment pathologic specimens, particularly in bone and soft tissue sarcomas. Current therapeutic protocols in North America require specific pathologic classification and stratify patients based on clinical, biologic, and pathologic features. For osteosarcoma, the pathologic response to therapy pre...

background: oxaliplatin (ox) significantly enhanced the antitumor activity of 5-fu in patients with advanced colorectal cancer and recently some phase ii trials have evaluated the feasibility and efficacy of oxaliplatin in neoadjuvant setting for treatment of locally advanced rectal cancer. on the other hand various studies have demonstrated that the overexpression of thymidylate synthase (ts) ...

As assessed by both standard histological staining and immunochemistry, intraperitoneal inoculation of C. burnetii in guinea pigs led to pathologic changes mainly in the liver, whereas intranasal inoculation led to pathologic changes mainly in the lungs. Myocarditis and positive blood cultures were observed only in those animals which received the highest inoculum. We therefore conclude that bo...