This paper described a simple preparation method for small-size and monodispersed lipid nanoparticles (LNPs) by using microfluidic devices. The fundamental role and importance of chaotic micromixer in the microfluidic device was demonstrated. The suitable cycle number of chaotic micromixer was confirmed for precise controlling LNPs size with narrow distribution under the any flow rate condition...

A parallel fully coupled implicit fluid solver based on a Newton–Krylov–Schwarz algorithm is developed on top of the Portable, Extensible Toolkit for Scientific computation for the simulation of microfluidic mixing described by the three-dimensional unsteady incompressible Navier–Stokes equations. The popularly used fractional step method, originally designed for high Reynolds number flows, req...

Microfluidic devices have become important part of technology nowadays in numerous fields application, such as chemical reactions, biosensors, synthesis nanomaterials, diagnostic device for detection biological samples, etc. In this work, a new fabrication approach, poly(dimethyl-siloxane) (PDMS) microstructures were integrated into PDMS microdevices by combining proton beam lithography and con...

We report for the first time a laminar high-performance continuous micromixing process of two fluids over a length of 200 microns in under 10 milliseconds achieved by an optimization of the control parameters amplitude and frequency in the mixing device denoted as 'Shear Superposition Micromixer'. We improve mixing time by approximately 5 orders of magnitude over diffusion-limited mixing. The d...

Liquid marble as a micromixer. Particles suspended in transparent liquid is dispersed time lapse photo. The colour change from red to purple shows the particle position first frame last frame.

A new type of dynamic micromixer combining the concepts of parallel multi-lamination and hydrodynamic focusing was developed for arbitrary control of disguised chemical selectivity.

Residence time control is an important indicator of micromixer design. When using vortex shedding to enhance mixing efficiency in a micromixer, the relationship between residence time and vortex shedding becomes important; if residence time is shorter than shedding time, the fluid elements flow through the channel too quickly with no contribution of vortex shedding to mixing. Both residence tim...

This work presents a parametric investigation on flow and mixing in a chaotic micromixer consisting of two-layer crossing channels proposed by Xia et al. (Lab Chip 5: 748-755, 2005). The flow and mixing performance were numerically analyzed using commercially available software ANSYS CFX-15.0, which solves the Navier-Stokes and mass conservation equations with a diffusion-convection model in a ...

We present a micromixer fabricated using MEMS technology which takes advantage of electroosmosis to mix fluids. A time dependent electric field is applied and the resulting electroosmosis perturbs the low Reynolds number flow. It is shown that the electric field can be deemed quasi-steady and the electroosmotic slip boundary condition can be applied when the incompressible Navier Stokes equatio...