OBJECTIVES The "dysregulated parturition" narrative posits that the human stress response includes a cascade of hormones that "dysregulates" and accelerates parturition but provides questionable utility as a guide to understand or prevent preterm birth. We offer and test a "strategic parturition" narrative that not only predicts the excess preterm births that dysregulated parturition predicts b...

The process of parturition involves the complex interplay of factors that change the excitability and contractile activity of the uterus. We have compared the relative gene expression profile of myometrium from rats before parturition (21 days pregnant) and during delivery, using high-density DNA microarray. Of 8,740 sequences available in the array, a total of 3,782 were detected as present. F...

the aim of the present study was to determine the effect of dietary supplementation of pioglitazone (pgt) during transition period on the ovarian function and the incidence of several diseases after parturition. eighty holstein cows were randomly allocatted to four treatment groups (n=20) using a 2×2 factorial design.  pioglitazone was fed for 14 day before the expected parturition time, or for...

background: the lori-bakhtiari sheep breed is one of the most common native breed in the south-western parts of iran. the peri-parturition period (2 weeks before to, 2 weeks after parturition), is generally of critical importance regarding the health, production and profitability of the ewes. objectives: this study was carried out to compare the serum concentrations of glucose, non-esterified f...

1. Although disrupted parturition and high foetal losses have previously been reported in pregnant rats maintained on zinc-deficient diets this is the first report to differentiate between the effects of reduced Zn intake and the effects of reduced food intake on the outcome of pregnancy in the rat. 2. Rats maintained on a 0.5 mg Zn/kg diet for the last 7 d of gestation or on a 5 mg Zn/kg diet ...

The objective of this study was to determine the relationships among daughter intramammary infections at first parturition and sire transmitting abilities for somatic cell score, udder type traits, productive life, and protein yield. Quarter milk samples from 958 daughters (in eight Pennsylvania herds and one Nebraska herd) of 182 Holstein sires were collected within a few days of first calving...

Blood samples were obtained sequentially from 10 dairy cows around the time of parturition to assess plasma fluctuations in estradiol-17β (E2) levels in association with those of several bone resorption markers. Plasma E2 concentration increased sharply a few days prepartum and decreased quickly after parturition. In terms of bone resorption markers, the plasma level of tartrate-resistant acid ...

Prostaglandins (PGs) have long been known to play roles in various processes of female reproduction; however, the molecular mechanisms therein remained unsolved until recently. This review summarizes the recent progress towards understanding the molecular mechanisms underlying PG actions in fertilization and parturition. A series of studies using EP2-deficient mice demonstrated that after ovula...

AIM The present study was conducted to evaluate the effect of risingtemperature on the metabolic as well as the reproductive performance of the black Bengal goat. MATERIALS AND METHODS A total 27 numbers of non-pregnant black Bengal goats of the same parity comprised the experimental animals. The selected goats were randomly assigned to 3 groups of 9 each, maintaining uniformity in body weigh...

Bovine neutrophils contain the enzyme acyloxyacyl hydrolase, which hydrolyzes the acyloxyacyl linkage of the two nonhydroxylated fatty acyl chains to two 3-hydroxy fatty acids in the highly conserved lipid A part of endotoxins with high specificity. This hydrolysis decreases the toxicity of lipid A, but the immunostimulatory capacity of endotoxins is largely maintained. In two trials, we studie...