Transdermal drug delivery systems (TDDS) are used to deliver the drug(s) or therapeutically active substances through topical route primarily skin. Relatively very small numbers of drugs administered transdermally because in many cases physical properties drugs, including polarity and molecular size, have limited its capacity particular dug transdermally. Now a day’s transdermal techniques vari...

Solid lipid nanoparticles are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, research and clinical medicine, as well as in other varied sciences. Solid lipid nanoparticle (SLN) dispersions have been proposed as a new type of colloidal drug carrier system suitable for intravenous administration. Solid lipid nanoparticles (...

curcumin is a hydrophobic polyphenol and major bioactive component of turmeric with known anti-inflammatory, neurogenesis, antioxidant, and anti-carcinogenic effect. curcumin antagonizes many steps in the inflammatory cascade, including inhibition of nf-κb (nuclear factor kappa-light-chain-enhancer of activated b cells), activator protein-1 transcription and inos (induced nitric oxide synthases...

ethosomes are a novel and alternative drug delivery systems and currently the focus of many research activities. ethosomes are soft, flexible vesicles that are composed mainly of phospholipids, ethanol and water. ethosomes can provide better skin permeation than liposomes and deliver enhanced amounts of both small and large therapeutic agents through skin and targeting to deeper skin layers for...

objective(s): nanoparticles (nps) are known for their specific accumulation in the inflamed tissues of the colon and thus allow a selective delivery to the site of inflammation with minimum adverse effects. the main objective of this work is to attain mesalamine loaded chitosan nanoparticles as a carrier for oral delivery. methods: in this study, mesalamine loaded chitosan nanoparticles were pr...

Despite the tremendous advancement in drug delivery, oral route remains the preferred route for the administration due to higher levels of patient compliance. But conventional forms offer no control over drug delivery, leading to fluctuations in plasma drug level. These have a disadvantage of a release all or nothing emptying process while the multiple unit particulate system pass through the g...

this review presents a brief outline of our current knowledge of the structure and chemical composition of the outer membrane vesicles (omvs), originating from the surface of gram negative bacteria including their outer membrane proteins and lipopolysaccharides. moreover, the functional roles and applications of omvs in medical research such as omv-based vaccines, omv adjuvants properties, omv ...

intravitreal injection is the most common approach for drug delivery to the posterior segment in humans. however, following the injection, drugs are rapidly eliminated from the vitreous, with half-lives up to a few days. depending on the rate of clearance from the vitreous, large boluses and frequent administrations may be required to ensure therapeutic levels over an extended period of time. m...

objective(s): in this research, zeolite x and zeolite y were used as vehicle to prepare intestine targeted oral delivery systems of indomethacin and ibuprofen. materials and methods: a soaking procedure was implemented to encapsulate indomethacin or ibuprofen within synthetic zeolites. gravimetric methods and ir spectra of prepared formulations were used to assess drug loading efficiencies into...

nowadays apphcanon of nanotubes in biology and medicinal science is more investigated. nanotubes can passthroueh cell walls and transport and release drugs in special tissues. the purpose of this paper is to investigatethe interaction of a nanotube having hydroxyl functional groups (oh) with an anticancer agent. in this worktransporting of an anticancer drug named 2-(2-amino 6,7-dimethyl pterid...