The tumor suppressor CYLD is a deubiquitinating enzyme that inhibits activation of the NF-kappaB, which has key roles in inflammation and apoptosis. We hypothesized that CYLD may regulate the NF-kappaB signaling pathway in cholesteatoma. We conducted immunohistochemistry to examine the expression of CYLD and NF-kappaB in 16 cases of cholesteatoma and paired cases of retroauricular (RA) skin. In...

Objective. Bilateral congenital cholesteatoma is a very rare condition. We describe the first case of an adult patient presenting with bilateral congenital cholesteatoma with labyrinthine fistula. Case report. We present a 34-year-old woman of bilateral congenital cholesteatoma with labyrinthine fistula, inducing leftsided mixed conductive-sensorineural hearing loss and vertigo, subsequently ac...

INTRODUCTION Acquired middle ear cholesteatoma can be classified as primary or secondary. Although both can result in hearing loss, it is still controversial whether there is an association between the type of cholesteatoma and the degree of hearing loss. OBJECTIVE To analyze the association between hearing loss and the type of acquired cholesteatoma, and the status of the ossicular chain. ...

Cholesteatoma is a serious otolaryngologic condition that to date remains an important problem and poses a challenge to otolaryngologists around the world. To improve the approach pertaining to the diagnosis and management of middle ear cholesteatoma, clear, clinically applicable, and useful definition and classification of cholesteatoma are required. This review aimed to evaluate the current a...

Background: Cholesteatoma is a collection of keratinized squamous epithelium in middle ear and pneumatic areas temporal bone. It can be said as an invasive disease which often associated with sensorineural hearing loss. seen that loss varies the location disease, duration extension cholesteatoma. Aims Objectives: The aim this study to see association cholesteatoma bone conduction threshold diff...

PURPOSE To assess the detection efficiency of Half-Fourier acquisition single-shot turbo spin-echo (HASTE) diffusion-weighted magnetic resonance imaging (MRI) for cholesteatoma. MATERIALS AND METHODS A total of 21 patients with suspected primary (n=16) or recurrent cholesteatoma (n=5) underwent MRI in a 1.5 Tesla scanner using an adapted protocol for cholesteatoma detection that included a co...

OBJECTIVE To evaluate the accuracy and sensitivity of diffusion-weighted magnetic resonance imaging with ADC value combined with MDCT in evaluating recurrent cholesteatoma. PATIENTS Thirty patients (20 females and 10 males), their age ranged from 10 to 40years, had undergone a tympanomastoid surgery for a cholesteatoma of the middle ear underwent MDCT and MR DWI examination before second- or ...

OBJECTIVE To determine hearing outcomes in young children receiving early and repeated tympanostomy tube insertion for recurrent acute otitis media or otitis media with effusion. DESIGN Prospective 14-year follow-up. SETTING Central Hospital of Central Finland, a tertiary care hospital. Patients Three hundred five consecutive infants and young children with otitis media received initial tym...

Introduction: Cholesteatoma is traditionally diagnosed by otoscopic examination and treated by surgery. The necessity for imaging in an uncomplicated case is controversial. This study was planned to investigate the usefulness of a preoperative high-resolution computed tomography (HRCT) scan in depicting the status of middle ear structures in the presence of cholesteatoma and also to compare the...