Proteinase-activated receptors (PARs) are a four-member family of G protein-coupled defined by their irreversible proteolytic mechanism activation. PARs have emerged as important regulators various physiological responses and implicated in numerous pathological conditions. Importantly, PAR1 PAR4 critical platelet function, while PAR2 is well established driver inflammatory responses. PAR-target...

Generalised Extreme Value models provide an interesting theoretical framework to develop closed-form random utility models. Unfortunately, few instances of this family are to be found as operational models in practice. The form of the model, based on a generating function G which must satisfy speci c properties, is rather complicated. Fundamentally, it is not an easy task to translate an intuit...

A main limitation of using conceptual models for predicting flow in ungauged catchments is the errors in identified relationships between calibrated conceptual parameters and known (or estimated) catchment descriptors. It is hypothesised here that these errors may be reduced if the modeller does not explicitly identify relationships, but applies all feasible models within a Bayesian averaging s...

An important aspect of support for distributed work is to enable users at different sites to work collaboratively; models need to be accessible by more than one user at a time allowing them to modify them independently from each other supporting parallel evolution [1]. As design is a largely creative process users also use layout to convey meaning. However, tools for merging such models tend to...

Implementing social concepts such as roles, norms and culture in agent-based models is complicated, especially if the modeller is not an experienced programmer. In this paper we present a web-based application that guides the modeller in defining social concepts in a way that would be feasible to code in an agent-based model. We illustrate the functioning of the software through a case study ma...

Kodkod, the backend of Alloy4, incorporates new features for solving models where part of the solution, that is, a partial instance, is already known. Although Kodkod has had this functionality for some time, it is not explicitly available to the modeller through the Alloy language syntax. We propose an extension to the Alloy language to make partial instances explicitly available to the Alloy ...

In this study, evidence for a factor secreted by bovine hypophyseal pars tuberalis that stimulates luteinizing hormone (LH) release from rat pars distalis cells is shown. The secretion products of bovine pars tuberalis cells into the culture medium were assayed on dispersed rat pars distalis cells in 30 min incubations and superfusion experiments. The culture medium from pars tuberalis total ce...