background: parkinson's disease is one of the prevalent degenerative diseases of the neural system. oxidative stress, which has been recognized as the most important factor of parkinson's disease, plays a main role in the death of neurons in this disease. antioxidants have a proved role in the prevention of oxidative stress. objective: considering the presence of evidence regarding antioxidant ...

background: free radical formation and oxidative stress might play an important role in the pathogenesis of parkinson's disease (pd). in vitro data indicate that neuromelanin (nm) pigment is formed the excess cytosolic catecholamine that is not accumulated into synaptic vesicles via the vesicular monoamine transporter 2 (vmat2). we designed this study to investigate the neuroprotective eff...

antioxidants have protective effects against free radicals-induced neural damage in parkinson's disease (pd). we examined the effects of ellagic acid (ea) on locomotion, pallidal local eeg, and its frequency bands' power and also cerebral antioxidant contents in a rat model of pd induced by 6-hydroxidopamine (6-ohda). 6-ohda (16 µg/2µ l) was injected into the right medial forebrain bundle (mfb)...

the aim of this work is to use self organizing map (som) for clustering of locomotion kinetic characteristics in normal and parkinson’s disease. the classification and analysis of the kinematic characteristics of human locomotion has been greatly increased by the use of artificial neural networks in recent years. the proposed methodology aims at overcoming the constraints of traditional analysi...

The effects of the inflammatory mediators involved in systemic lupus erythematous (SLE) on subsequent Parkinson disease have been reported, but no relevant studies have focused on the association between the 2 diseases. This nationwide population-based study evaluated the risk of Parkinson disease in patients with SLE.We identified 12,817 patients in the Taiwan National Health Insurance databas...

INTRODUCTION This epidemiological survey estimates the hospitalization burden related to Parkinson´s Disease in Spain. METHODS This observational retrospective survey was performed by reviewing data from the National Surveillance System for Hospital Data, which includes more than 98% of Spanish hospitals. All hospitalizations of patients with Parkinson´s disease that were reported from 1997-2...

OBJECTIVE To investigate whether serum vitamin D level predicts the risk of Parkinson disease. DESIGN Cohort study. SETTING The study was based on the Mini-Finland Health Survey, which was conducted from 1978 to 1980, with Parkinson disease occurrence follow-up through the end of 2007. During the 29-year follow-up period, 50 incident Parkinson disease cases occurred. Serum 25-hydroxyvitamin...

BACKGROUND Sex differences in Parkinson disease clinical features have been reported, but few studies have examined sex influences on use of dopaminergic medication in early Parkinson disease. The objective of this study was to test if there are differences in the type of dopaminergic medication used and levodopa equivalent daily dose between men and women with early Parkinson disease enrolled ...

PURPOSE To determine whether the proton spectra from patients with clinically diagnosed Parkinson disease differ from the spectra of age-matched healthy subjects with respect to the major cerebral metabolite resonances as well as lactate. METHODS Fourteen patients with Parkinson disease (38 to 81 years of age) and 13 healthy control subjects (37 to 81 years of age) were studied using image-gu...