نتایج جستجو برای: parkinson
تعداد نتایج: 68985 فیلتر نتایج به سال:
Diffusion tensor tractography was used to evaluate whether diffusion metrics in the nigrostriatal pathway could diagnose Parkinson disease. Diffusion tensor imaging was performed on 30 patients with Parkinson disease and 32 healthy controls by using a 3.0 Tesla magnetic resonance imaging system. Diffusion tensor tractography was used for both groups to visualize the nigrostriatal and corticospi...
Increased somatic mitochondrial DNA (mtDNA) mutagenesis causes premature aging in mice, and mtDNA damage accumulates in the human brain with aging and neurodegenerative disorders such as Parkinson disease (PD). Here, we study the complete spectrum of mtDNA changes, including deletions, copy-number variation and point mutations, in single neurons from the dopaminergic substantia nigra and other ...
Parkinson disease is a neurological disorder. In this disease control over body muscles get disturbed. In almost 90% of the cases, people suffering from Parkinson disease (PD) have speech disorders. The goal of the paper is to differentiate healthy and PD affected persons using voice analysis. There are no well-developed lab techniques available for Parkinson detection. Parkinson detection usin...
BACKGROUND Parkinson disease frequently causes difficulty turning that can lead to falls, loss of independence, and diminished quality of life. Turning in tight spaces, which may be particularly impaired in Parkinson disease, is an essential part of our daily lives, yet a comprehensive analysis of in-place turning has not been published. OBJECTIVE This study was conducted to determine whether...
Eine frühe Diagnose der Parkinsonkrankheit ist enorm wichtig, da klinische Symptome erst sichtbar werden, wenn schon ein Großteil der betroffenen Nervenzellen unwiderruflich geschädigt ist. Neuere Arbeiten deuten darauf hin, daß mit der transkraniellen Sonografie (TCS) ein Werkzeug verfügbar ist, das die Manifestation einer genetischen Form der Parkinson-Krankheit bereits zu einem sehr frühen Z...
BACKGROUND Mutations in the PTEN-induced kinase (PINK1) gene located within the PARK6 locus on chromosome 1p35-p36 have recently been identified in patients with recessive early-onset Parkinson disease. OBJECTIVE To assess the prevalence of PINK1 mutations within a series of early- and late-onset Parkinson disease patients living in North America. DESIGN All coding exons of the PINK1 gene w...
DJ-1 is a multifunctional protein that plays an important role in oxidative stress, cell death, and synucleinopathies, including Parkinson disease. Previous studies have demonstrated that total DJ-1 levels decrease in the cerebrospinal fluid, but do not change significantly in human plasma from patients with Parkinson disease when compared with controls. In this study, we measured total DJ-1 an...
Recent findings Mutations in VPS35 were identified as a novel cause of autosomal dominant Parkinson disease using exome sequencing. Next generation sequencing (NGS) was also used to identify PRRT2 mutations as a cause of paroxysmal kinesigenic dyskinesia (DYT10). Using a different technique, that is linkage analysis, mutations in EIF4G1 were implicated as a cause of Parkinson disease and mutati...
background: parkinson's disease as a progressive disorder of the nervous system leads to the disability of postural control system. objectives: in the present study the effects of pilates exercises on functional balance in patients with parkinson's was investigated. materials and methods: this control trial included 30 patients with idiopathic parkinson's disease who were selecte...
Introduction: Parkinson’s disease (PD) is the second most neurodegenerative disorder which is characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Clinical symptoms do not appear until approximately 70% of dopaminergic neurons and 80% of the striatal dopaminergic terminals have been lost. Thus, detecting nonclinical factors such as detecting b...
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