نتایج جستجو برای: parathyroid carcinoma

تعداد نتایج: 409366  

Journal: :The Journal of clinical endocrinology and metabolism 2001
E Shane

Parathyroid carcinoma is an uncommon cause of PTHdependent hypercalcemia. The collective published experience with this rare neoplasm has provided a distinctive clinical profile that differs in a number of respects from that of benign primary hyperparathyroidism (1–3). The distinguishing features of parathyroid carcinoma assume even greater prominence when viewed within the current context of p...

2012
Areej Khan Yusra Khan Shahzad Raza Ghulam Akbar Monis Khan Nauman Diwan Wajih Rizvi

Parathyroid cysts are rare lesions found in the neck and anterior mediastinum. They are often nonfunctional (>90%) and rarely in the functional form. This paper discusses a case of severe hypercalcemia (23 mg/dL) secondary to a rare functional parathyroid cyst. The patient was later found to have a hemorrhagic cyst with compression of the right recurrent laryngeal nerve. Preoperative diagnosis ...

2017
Yuan Gao Cheng Yu Feixiang Xiang Mingxing Xie Lingyun Fang

RATIONALE Parathyroid carcinoma is a rare endocrine malignancy. Acute pancreatitis as an initial manifestation of parathyroid carcinoma has been rarely reported. PATIENT CONCERNS A 22-year-old woman was admitted to emergency room with a sudden attack of severe epigastric pain. DIAGNOSES Acute pancreatitis was diagnosed as elevated levels of serum amylase. During the work-up for acute pancre...

Journal: :Endocrines 2022

Parathyroid carcinoma is a rare disease that needs an additional diagnostic tool and wide therapeutic options. The genomics proteomics approach may help to find the tools improve prognosis of by early detection metastatic control. findings from were mainly CDC73, PRUNE2, CCND1, genes related PI3K/AKT/mTOR Wnt pathways. CCND1 closely each other, PRUNE2 are expression levels parafibromin protein,...

Journal: :Cancer research 2004
Carola J Haven Viive M Howell Paul H C Eilers Robert Dunne Masayuki Takahashi Marjo van Puijenbroek Kyle Furge Job Kievit Min-Han Tan Gert Jan Fleuren Bruce G Robinson Leigh W Delbridge Jeanette Philips Anne E Nelson Ulf Krause Henning Dralle Cuong Hoang-Vu Oliver Gimm Hans Morreau Deborah J Marsh Bin T Teh

Parathyroid tumors are heterogeneous, and diagnosis is often difficult using histologic and clinical features. We have undertaken expression profiling of 53 hereditary and sporadic parathyroid tumors to better define the molecular genetics of parathyroid tumors. A class discovery approach identified three distinct groups: (1) predominantly hyperplasia cluster, (2) HRPT2/carcinoma cluster consis...

Journal: :Turk patoloji dergisi 2015
Kai Duan Özgür Mete

Parathyroid carcinoma is a rare type of endocrine cancer, with significant morbidity and mortality associated with parathyroid hormone (PTH)-mediated hypercalcemia. Concerning clinical features for parathyroid cancer include severe hypercalcemia (albumin-corrected calcium > 3 mmol/L), a palpable neck mass ( > 3 cm), 3rd/2nd generation PTH assay ratio ( > 1), and intraoperative suspicion of loca...

2013
Lizette Vila Duckworth William E. Winter Mikhail Vaysberg César A. Moran Samer Z. Al-Quran

Intrathyroidal parathyroid carcinoma is an exceedingly rare cause of primary hyperparathyroidism. A 51-year-old African American female presented with goiter, hyperparathyroidism, and symptomatic hypercalcemia. Sestamibi scan revealed diffuse activity within an enlarged thyroid gland with uptake in the right thyroid lobe suggestive of hyperfunctioning parathyroid tissue. The patient underwent t...

2017
Nobuyasu Suganuma Hiroyuki Iwasaki Satoru Shimizu Tatsuya Yoshida Takashi Yamanaka Izumi Kojima Haruhiko Yamazaki Soji Toda Hirotaka Nakayama Katsuhiko Masudo Yasushi Rino Kae Kawachi Yohei Miyagi Akio Miyake Kenichi Ohashi Munetaka Masuda

BACKGROUND Non-functioning parathyroid carcinoma is a rare disease that is difficult to distinguish from other diseases based on the lack of hyperparathyroidism. This is a report of non-functioning parathyroid carcinoma diagnosed by reverse transcription polymerase chain reaction (RT-PCR) targeting parathyroid hormone (PTH) messenger RNA. CASE PRESENTATION The patient is a 67-year-old male wh...

2015
AR Walton MR Formby AS Ravi Kumar

Parathyroid carcinoma is a rare cause of primary hyperparathyroidism. Clinical indicators of carcinoma include the severity of hyperparathyroidism and presence of a palpable neck mass. Definitive diagnosis requires surgical resection and specimen histology, or documentation of metastatic disease. We present a case of parathyroid carcinoma in a young female patient with severe hyperparathyroidis...

2015
Abd Elmaksoud M. Abd Elmaksoud Iman G. Farahat Mahmoud M. Kamel

BACKGROUND AND OBJECTIVES Total thyroidectomy is indicated in most cases with postcricoid carcinoma, circumferential hypopharyngeal carcinoma and in advanced laryngeal carcinoma. Persistent hypoparathyroidism is a frequent complication after total thyroidectomy which is difficult to manage unlike hypothyroidism. This study was to assess the feasibility of parathyroid gland autotranplantation af...

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