The presence of a pro-oxidant state in patients with schizophrenia may account for the increased risk atherosclerosis and cardiovascular disease this group supports potential utility circulating biomarkers oxidative stress stratification management. We investigated issue by conducting systematic review meta-analysis association between concentrations paraoxonase-1, an antioxidant calcium-depend...

Human serum paraoxonase (PON) associated with high density lipoprotein (HDL) , has been postulated to have a role in protecting low-density lipoprotein (LDL) against oxidative damage, which has led to the proposal that PON is an anti-atherogenic and anti-inflammatory enzyme. It has genetic polymorphism at the 191 (R ->Q) and two alloenzymes A and B and three phenotypes A, B, and AB. We exa...

OBJECTIVE Newborn infants, particularly preterm infants, are at greater risk of oxidative stress because of an imbalance between high oxidant loads and immature antioxidant defenses. In several studies, the activities of serum paraoxonase (PON) and arylesterase (ARE) have been found to decline in patients under increased oxidative stress. We investigated the relationships between PON-1 and ARE ...

In an effort to identify genetic factors contributing to atherogenesis, we have studied inbred strains of mice that are susceptible (C57BL/6J) and resistant (C3H/HeJ) to diet-induced aortic fatty streak lesions. When maintained on a low-fat diet, HDL isolated from both strain C57BL/6J (B6) and C3H/HeJ (C3H) mice protect against LDL oxidation in a coculture model of the artery wall. However, whe...

Human serum paraoxonase contributes to the anti-atherogenic effect of high-density lipoprotein cholesterol (HDL-C) and has been shown to protect both low-density lipoprotein cholesterol (LDL-C) and HDL-C against lipid peroxidation. We investigated the effects of rosiglitazone on paraoxonase activity and metabolic parameters in patients with type 2 diabetes mellitus [50 patients (30 males, 20 fe...

Equilibrium dialysis and Scatchard plots were used to establish that human and rabbit paraoxonases both have two calcium binding sites. Independent-site and stepwise constant analyses were used to calculate a higher affinity site (Kd1) of 3.6 +/- 0.9 x 10(-7) M for human A paraoxonase, and 1.4 +/- 0.5 x 10(-8) M for rabbit paraoxonase, and a lower affinity site (Kd2) of 6.6 +/- 1.2 x 10(-6) M f...

BACKGROUND The aim of this study was to evaluate the association of maternal serum 25-hydroxyvitamin D, paraoxonase 1, and neutrophil-to-lymphocyte ratio in women having early spontaneous preterm birth without clinical chorioamnionitis. MATERIAL AND METHODS This study was prospectively administered in women referred to our obstetrics service with preterm labor that resulted in preterm birth (n=...

OBJECTIVES Oxidative stress and inflammation are important processes in development of atherosclerosis. Paraoxonase 1 (PON1) is a bioscavenger enzyme associated with inflammation and oxidative stress. We evaluate the association of two single nucleotide polymorphisms in PON1 gene, and enzyme activities with lipid profile and glycemia. METHODS This case-control study consisted of 126 patients ...

conclusions the present study has demonstrated that a combination of exercise and silymarin can improve body composition and adiponectin levels. background silymarin has powerful antioxidant properties, but its effects on athletic performance are poorly understood. objectives the present study was undertaken to evaluate the effects of 4 weeks of endurance or strength exercise, with or without s...