Volume 86, Number 11 www.aafp.org/afp American Family Physician 1065 A 19-year-old woman presented with a red rash on her face. The nonpainful bumps had been present for several years and had been unsuccessfully treated with topical retinoids and laser therapy. The patient had a history of seizure disorder and mental retardation. The examination revealed multiple erythematous papules coalescing...

The histopathology of Gottron's papules has not been often reported. Morphological descriptions of these lesions are mainly focused on changes of the epidermis and interface, and on the nature of the inflammatory infiltrate. Dilated vascular vessels of Gottron's papules are rarely mentioned in the literature. We studied these vessels in a biopsy specimen obtained from Gottron's papule in a 65-y...

The patient was a 24-year-old black woman with no past history of interest, who was seen for asymptomatic lesions on the margins of both hands and in the creases of both palms. The lesions had progressively increased in number over a period of 2 years. In her family history, it was found that her father and 1 brother had similar lesions on the margins of the hands and feet. Physical examination...

A 56-year-old male patient was seen in the dermatology clinic for a 25-year history of an asymptomatic cluster of violaceous papules in a coalescing pattern on the right lateral thigh (Figure 1). No other significant findings were found on physical exam and all laboratory results were within normal demographic ranges. The patient reported to have hypothyroidism that was diagnosed one year ago a...

Human subjects were infected with Haemophilus ducreyi. All subjects developed papules and were randomized to treatment with a single dose of azithromycin (1 g) or ciprofloxacin (500 mg). At weekly intervals, volunteers were reinoculated with H. ducreyi, and drug concentrations were measured in peripheral blood mononuclear cells (PBMC). When papules developed, the subjects were treated with anti...

Case 1 A 39-year-old Japanese man presented with 6-month history of a group of papules on the chest (Figure 1A). The patient had no specific symptoms, such as itching or tenderness, but visited the clinic worried about the long duration of the lesions. Physical examination showed pinkish white, firm papules of 5 to 10 mm in diameter with sharply demarcated borders. The surface of the papules wa...