Insulin-like growth factor (IGF)-I stimulates vascular smooth muscle cell (VSMC) migration and proliferation, which are fundamental to neointimal hyperplasia in postangioplasty restenosis. IGF-I action is modulated by several high-affinity IGF binding proteins (IGFBPs). IGFBP-4 is the predominant IGFBP produced by VSMCs and is a potent inhibitor of IGF-I action. However, specific IGFBP-4 protea...

The insulin-like growth factor (IGF) signaling pathway is involved in certain human cancers, and the feasibility of directly targeting the IGF receptor has been actively investigated. However, recent evidence from clinical trials suggests that this approach can be problematic. We have developed an alternative strategy to indirectly inhibit the IGF signaling by targeting the metalloproteinase, p...

s 1. Abizaid A, Mezei G, Horvath TL. (2003) Estradiol enhances light induced fos immunoreactivity (Fos-IR) within the suprachiasmatic nucleus (SCN) of ovarectomized (OVX) female rats. Program No. 511.3 Neuroscience Abstract, New Orleans, LA, USA: Society of Neuroscience, 2003. Online IF: 8.306 2. Abizaid A, Mezei G, Horvath TL. (2003) Estradiol enhances neuronal activation in the SCN of female ...

OBJECTIVE To describe the association between pregnancy associated plasma protein A (PAPP-A), alpha-fetoprotein (AFP) and adverse perinatal outcome. METHODS We conducted a multicenter prospective cohort study of 8,483 women attending for prenatal care in southern Scotland between 1998 and 2000. The risk of delivering a small for gestational age infant, delivering preterm, and stillbirth were ...

BACKGROUND Pregnancy-associated plasma protein A (PAPP-A) has been suggested as a candidate marker for the identification of unstable plaques in coronary arteries. We assessed the value of PAPP-A for predicting short-term cardiovascular events in a large cohort of patients presenting with cardiac chest pain. METHODS We included consecutive patients who presented to a teaching hospital in Germ...

OBJECTIVE To study PAPP-A and SP1 for biochemical trisomy screening in twin pregnancies and to investigate the role of maternal and placental compartments in marker production by comparing the levels of the decidual cytokine M-CSF with the PAPP-A and SP1 from the placenta. METHODS Thirteen twin pregnancies with at least one chromosomally abnormal fetus were compared with 68 normal twin pregna...

Growth hormone (GH) and its mediator, insulin-like growth factor-1 (IGF-1), play a critical role in human growth. In circulation, IGF-1 is found in a ternary complex with IGF binding proteins (IGFBPs) and acid labile subunit (ALS) but little attention has been paid to the regulation of IGF-1 bioavailability. Recently, pregnancy-associated plasma protein-A2 (PAPP-A2) and stanniocalcin-2 (STC2) w...

OBJECTIVE To elucidate transport of intrafollicular proteins Inhibin A and pregnancy-associated plasma protein A (PAPP-A) across the follicular fluid (FF)/blood barrier. DESIGN A retrospective study. SETTING IVF lab at a university hospital, academic, and industrial research labs. PATIENT(S) Fifty-five women undertook the IVF program. INTERVENTION(S) Follicular fluid aspirations and ana...