BACKGROUND Variance in microarray studies has been widely discussed as a critical topic on the identification of differentially expressed genes; however, few studies have addressed the influence of estimating variance. METHODOLOGY/PRINCIPAL FINDINGS To break intra- and inter-individual variance in clinical studies down to three levels--technical, anatomic, and individual--we designed experime...

This paper describes XRCE’s participation in Large Scale Visual Concept Detection and Annotation Task [16] and Photo Retrieval Task [17] of ImageCLEF 2009. Those tasks both use a new collection which is different and which is much larger than the ones used in past sessions. Moreover, new kinds of challenge to tackle were designed such as new categories to detect or new types of topic to deal wi...

PURPOSE To demonstrate the cross-sectional anatomy in acute commotio retinae. METHODS A 27-year-old male with unilateral decreased vision after acute blunt ocular trauma, was examined by optical coherence tomography (OCT). RESULTS Visual acuity was 20/20 OD and 20/50 OS. Fundus examination OS demonstrated a mild edema in the papillomacular and foveal area. OCT confirmed a separation of the ...

Choroidal osteoma is a rare intraocular bony tumor that typically manifests as a yellow-white, well-demarcated mass with geographic pseudopodal margins.1-3 This benign tumor predominantly occurs in the peripapillary or papillomacular region, most often in young women.1,2 Occasionally, choroidal osteoma can simulate an amelanotic choroidal tumor such as melanoma, nevus, or metastasis.1,2 This tu...

The techniques used and the outcome in eyes treated for retinal detachment associated with choroidal coloboma are described. We reviewed the medical reports on five eyes of five patients with retinal detachment associated with choroidal coloboma who underwent vitrectomy. Retinal breaks were identified at the margin of or within the coloboma and the retina was successfully reattached by vitrecto...

The authors show by illustration that procedures used to validate the reliability of single-concentration high-throughput screens such as the signal window and Z' factor do not ensure sufficient reliability in potency estimates from concentration response assays. They develop the minimum significant ratio as a statistical parameter to characterize the fold change between 2 compounds run in the ...

In this work we present a probabilistic model to estimate summaries of Affymetrix GeneChip probe level data. Comparisons with two different models were made both on a publicly available dataset and on a study performed in our laboratory, showing that our model performs better for consistency of fold change.

Biochemical regulatory networks governing diverse cellular processes such as stress-response, differentiation and cell cycle often contain coupled feedback loops. We aim at understanding how features of feedback architecture, such as the number of loops, the sign of the loops and the type of their coupling, affect network dynamical performance. Specifically, we investigate how bistability range...

In this work, we study the volume ratio of the projective tensor products `p ⊗π `q ⊗π `r with 1 ≤ p ≤ q ≤ r ≤ ∞. We obtain asymptotic formulas that are sharp in almost all cases. As a consequence of our estimates, these spaces allow for a nearly Euclidean decomposition of Kašin type whenever 1 ≤ p ≤ q ≤ r ≤ 2 or 1 ≤ p ≤ 2 ≤ r ≤ ∞ and q = 2. Also, from the Bourgain-Milman bound on the volume rat...