In recent years, autoimmune pancreatitis has been established as a special type of chronic pancreatitis. It is characterized by its histopathological and immunological features. The morphological hallmarks are periductal infiltration by lymphocytes and plasma cells and granulocytic epithelial lesions with consequent destruction of the duct epithelium and venulitis. Autoimmune pancreatitis has t...

EDITORIAL SYNOPSIS Two hundred and five confirmed cases of pancreatitis have been classified. Primary calcifying pancreatitis is associated with alcoholism. Pancreatic changes are patchy and related to plugging of minute ducts. Cysts are frequent. Obstruction to the main pancreatic duct may also result in chronic pancreatitis. Acute pancreatitis and acute recurrent pancreatitis are often associ...

CONTEXT Release of oxygen free radicals is increased in acute pancreatitis, but whether this can be used to predict clinical severity is not known. OBJECTIVE This study assesses whether plasma concentrations of malondialdehyde (a marker of lipid peroxidation) and superoxide dismutase (an oxygen free radical scavenger) can be used to predict severity of acute pancreatitis. PATIENTS Fifty-one...

OBJECTIVES In this study, we tested the hypothesis that hypertonic saline exerts anti-inflammatory effects by modulating hepatic oxidative stress in pancreatitis. INTRODUCTION The incidence of hepatic injury is related to severe pancreatitis, and hypertonic saline reduces pancreatic injury and mortality in pancreatitis. METHODS Wistar rats were divided into four groups: control (not subject...

BACKGROUND The biological basis of pain in chronic pancreatitis is poorly understood. Mast cells have been implicated in the pathogenesis of pain in other conditions. We hypothesized that mast cells play a role in the pain of chronic pancreatitis. We examined the association of pain with mast cells in autopsy specimens of patients with painful chronic pancreatitis. We explored our hypothesis fu...

Chronic pancreatitis Chronic pancreatitis, that is chronic progressive replacement fibrosis of the pancreas, is a rare disease in this country. I have collected fifty-five cases (thirty-six women and nineteen men) who illustrate some aspects of the disease, but I have had to rely on the literature for most of my information. The literature on chronic pancreatitis has been very confused and one ...

Artificial neural networks are intelligent systems that have successfully been used for prediction in different medical fields. In this study, the efficiency of a neural network for predicting the survival of patients with acute pancreatitis is compared with days-of-survival obtained from patients. A three- layer back-propagation neural network was developed for this purpose. Clinical data (e.g...

Chronic pancreatitis is an inflammatory disease well known for its epidemiological and clinical aspects, but still obscure as to its aetiology and pathogenesis [1]. Alcohol has been identified to be the cause of the disease, since the largest number of patients suffering from chronic pancreatitis were found to have consumed large quantities of wine or spirits over a long period of time [2, 3, 4...

UNLABELLED The initiation and progression of acute pancreatitis is associated with disturbances in pancreatic microcirculatory. Microcirculatory disorders contribute to multiorgan dysfunction syndrome in the course of acute pancreatitis. The aim of this study was to determine the influence of heparin administration on the development and the course of ischemia/reperfusion-induced pancreatitis. ...

Pancreatitis is a disease which is caused by inflammation of the pancreas. Pancreas is a large gland that is damaged when digestive enzymes are become activated before releasing into small intestine and these digestive enzymes attack the pancreas. There are two main types of pancreatitis, one is acute pancreatitis and the other is chronic pancreatitis. The pain sometimes goes into the back. Fev...