introduction and aims: microscopic colitis has been generally recognized as lymphocytic colitis and collagenous colitis: two inflammatory diseases of large intestine without a definite origin. the colon appears normal by colonoscopy. so, biopsy of the colonic mucosa is mandatory for diagnosis. materials and methods: as a descriptive design we assessed epidemiological, clinical and laboratory fi...

some dermatologic manifestations are common in ulcerative colitis (uc). herein, we present a 36-year-old woman with ulcerative colitis and uncommon nasal mucosa pyoderma vegetans. the patient presented to our hospital with symptoms of active colitis and a concomitant 3×4×5 cm dermato-mucosal lesion in her left nasal lumen. after surgery of the mucosal lesion, the treatment for her active coliti...

This case describes a female patient with a long history of pan-colitis (>10 years) with a recent flare of disease precipitated by a Clostridium difficile infection (CDI) after experiencing septic arthritis. The CDI was successfully treated with vancomycin confirmed by a negative PCR test. The patient then experienced a flare of ulcerative colitis (UC) with 7-8 watery, bloody stools per day wit...

It has been hypothesized that dysregulated host/microbial interactions play a pivotal role in the pathogenesis of inflammatory bowel disease. However, the exact mechanisms underlying the induction and perpetuation of the intestinal disorder are unclear. Recently, we unexpectedly discovered significantly upregulated gene expression of chitinase 3-like-1 in inflamed colon of the dextran sulfate s...

Background: Chronic diarrhea is a common problem in patients with symptoms related to gastro-intestinal tract. Some of these patients present with chronic non-bloody, watery diarrhea and no specific clinical, laboratory, or endoscopic findings. The aim of the present study was to investigate the value of histological findings in patients with chronic diarrhea who have normal or non-specific end...

Objective(s): Ulcerative colitis (UC) is a kind of complex immune disease, and a major cause of destruction of intestinal barrier and oxidative stress in this field. In this paper, glutamine (Gln) was believed to offer protection against oxidative stress injury in colitis mice.Materials and Methods: Thirty mice were randomly assigned int...

Ulcerative colitis (UC) is defined as an idiopathic inflammatory disorder primarily involving the mucosa and submucosa of the colon. UC-associated colon cancers (also known as colitic cancers) develop through the inflammation-dysplasia sequence, which is a major problem affecting the prognosis of patients with UC. It is therefore very important to detect malignancy from UC at an early stage. As...

Ipilimumab is a human monoclonal antibody that functions as a cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) inhibitor that is used to treat malignant melanoma. Due to ipilimumab's removal of immune regulation, specifically through the inactivation of CTLA-4, it is commonly associated with inflammatory and autoimmune events. Gastrointestinal (GI) related immune-related adverse events such...

TOPIC: Critical Care TYPE: Medical Student/Resident Case Reports INTRODUCTION: Infectious and inflammatory colitis such as salmonella enterocolitis ulcerative rarely coexist in the same individual. While often self-limiting, certain pathogens a non-typhoid can contribute to significant morbidity mortality patients with underlying colitis. Prompt recognition treatment is important these order im...