نتایج جستجو برای: pamps
تعداد نتایج: 826 فیلتر نتایج به سال:
Candida albicans infections range from superficial to systemic and are one of the leading causes fungus-associated nosocomial infections. The innate immune responses during these various infection types differ, suggesting that host environment plays a key role in modulating host–pathogen interaction. In addition, C. is able remodel its cell wall response environmental conditions evade clearance...
OBJECTIVE Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. In sepsis and septic shock, pathogen-associated molecular pattern molecules (PAMPS), such as bacterial exotoxins, cause direct cellular damage and/or trigger an immune response in the host often leading to excessive cytokine production, a maladaptive systemic inflammatory respo...
Here we describe development of an extracorporeal hemoadsorption device for sepsis therapy that employs commercially available polysulfone or polyethersulfone hollow fiber filters similar to those used clinically for hemodialysis, covalently coated with a genetically engineered form of the human opsonin Mannose Binding Lectin linked to an Fc domain (FcMBL) that can cleanse a broad range of path...
Introduction The induction of an appropriate immune response upon infection of an invading pathogen is controlled by host pattern recognition receptors (PRRs)* that specifically recognise essential structural components of infectious agents termed pathogen-associated molecular patterns (PAMPs) (1-3). Detection of PAMPs by PRRs triggers intracellular signalling pathways leading to the expression...
Adjuvants were reintroduced into modern immunology as the dirty little secret of immunologists by Janeway and thus began the molecular definition of innate immunity. It is now clear that the binding of pathogen-associated molecular patterns (PAMPs) by pattern recognition receptors (PRRs) on antigen presenting cells (APCs) activates the innate immune response and provides the host with a rapid m...
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