Despite the limited efficacy of current medical treatments, and the fact that they only treat the pain component of chemotherapy-induced peripheral neuropathy (CIPN), until recently there has been little interest in exploring surgical therapies for this condition. This is not at all surprising, because at first blush, it would seem that there is no rationale for a surgical approach to a systemi...

Painful neuropathy is a common complication of diabetes. Particularly in the early stage of diabetic neuropathy, patients are characterized by burning feet, hyperalgesia to heat, and mechanical stimuli, as if residual nociceptors were sensitized. Such symptoms are barely explained by common pathophysiological concepts of diabetic neuropathy. Diabetes was induced in Wistar rats by streptozotocin...

Emerging evidence suggests that dyslipidemia is an independent risk factor for diabetic neuropathy (DN) (reviewed by Vincent et al. 2009). To experimentally determine how dyslipidemia alters DN, we quantified neuropathic symptoms in diabetic mice fed a high-fat diet. Streptozotocin-induced diabetic C57BL/6 mice fed a high-fat diet developed dyslipidemia and a painful neuropathy (mechanical allo...

Objective To assess the effect of vitamin D supplementation on neuropathy specific quality of life (NeuroQoL) in patients with painful diabetic neuropathy. Methods This prospective, open label study was conducted between June 2012 and April 2013. Patients with symptomatic diabetic neuropathy were given a single dose of 600,000 IU intramuscular vitamin D, and NeuroQol was assessed at baseline ...

Abstract Background Diabetes mellitus is commonly complicated by diabetic peripheral neuropathy. Poor adherence to medication common in neuropathy mainly due side effects and poor tolerance medication. Botulinum toxin A intradermal injection has proved efficacy cases of neuropathy, however there a need compare its effect other lines treatment. The aim the study was type versus conventional oral...

Background and aim Damage to small nociceptive fibres may contribute painful diabetic neuropathy. We aimed compare large nerve fibre measurements together with skin biopsy corneal confocal microscopy in patients type 1 diabetes or painless Methods have assessed the McGill pain questionnaire, neuropathy disability score, vibration perception threshold, warm cold sensation thresholds, electrophys...

Observations have been made on nine cases of painful diabetic neuropathy of acute onset. All cases were male and all were associated with and preceded by precipitous and severe weight loss. The pain was of a continuous burning quality and experienced mainly in the legs, especially distally. Contact discomfort of the skin was often a troublesome feature, but sensory loss was mild or absent, and ...

Abstract Background Diabetes mellitus (DM) is a metabolic disease which complicated by occurrence of diabetic peripheral neuropathy (DPN). Vitamin D deficiency contributes to the etiology and progression type 2 DM development micro-vascular complications so in this study we assessed vitamin level patients evaluate association between assess if there relationship with certain subtypes neuropathy...