Dissolution testing is useful for controlling the quality of an oral generic equivalent (GE) drug and rejecting a bioinequivalent GE. However, several sources of variability in dissolution tests can affect evaluations of drug quality. Recently, we reported that shifting the paddle shaft off-center significantly changed the dissolution rate of sodium diclofenac tablets, with the result that some...

BACKGROUND The skin paddle of the fibula osteoseptocutaneous flap is reliably vascularized by septocutaneous perforators from the peroneal artery. However, in 5 to 10 percent of lower limbs, these perforators are absent. This anatomical study evaluated use of the soleus musculocutaneous perforator for skin paddle salvage in such situations. METHODS Latex injection studies were performed on 20...

Although not listed on the United States Pharmacopeia (USP), like standard USP 2, small volume USP 2 dissolution apparatus has gained a great deal of attention, especially for cases where small amount of drug product is available for testing in research and design step or evaluations are to be made on a tablet containing trace amounts of the active pharmaceutical ingredient. In this work, first...

The performance of the electric submersible pump (ESP) significantly affected by Gas Void Fraction (GVF). Thus, using of a Rotary Gas Separator (RGS) is a suitable solution for this issue. The performance of the RGS is function of different parameters such as geometry of impeller, rotating speed, boundary conditions, media viscosity and GVF. In this study, the influences of GVF, viscosity, and ...

The copper paddle-wheel is the building unit of many metal organic frameworks. Because of the ability of the copper cations to attract polar molecules, copper paddle-wheels are promising for carbon dioxide adsorption and separation. They have therefore been studied extensively, both experimentally and computationally. In this work we investigate the copper-CO2 interaction in HKUST-1 and in two ...

Drug dissolution studies are commonly conducted using compendial methods employing USP Paddle and Basket apparatuses. In many cases, dissolution studies can be of limited benefit especially for product-dependent dissolution procedures like in extended release (ER) formulations. The high variability in dissolution testing, that is not productrelated, emphasizes the need for developing new method...

amount of myocardium. Am J Cardiol 36: 37, 1975 5. Ewy GA: Defibrillation paddle electrodes. Proceedings of the Cardiac Defibrillation Conference, Purdue University, West Lafayette, Indiana, 1975, p 39 6. Ewy GA: Effectiveness of direct current defibrillation. Role of paddle electrode size. I1. Am Heart J 93: 674, 1977 7. Rush S, Lepeschkin E, Gregaritsch A: Current distribution from defibrilla...

This paper describes the characteristics of small-amplitude waves generated by a sinusoidally oscillating, inclined paddle-type wavemaker operating in a constant-depth channel. Two-dimensional, linearized potential flow is assumed. A semi-analytical method, the boundary collocation method, is used to establish the relationship between wave amplitude and paddle stroke. The numerical results are ...