metabolic syndrome (mets) is characterized by a cluster of cardiovascular risk factors that include: abdominal obesity, dyslipidaemia, hypertension, insulin resistance and impaired glucose tolerance. recent genome wide association studies have identified several susceptibility regions involved in lipid metabolism that are also associated with mets. we have explored the association of 9 genetic ...

In this study, we aimed to determine the potential association of MTHFR tagging single nucleotide polymorphisms (SNPs) with risk of developing esophagogastric junction adenocarcinoma (EGJA). MTHFR rs1801133 G>A, rs3753584 T>C, rs4845882 G>A, rs4846048 A>G and rs9651118 T>C polymorphisms were genotyped in 1,677 healthy individuals and 1,063 patients with EGJA. We found that MTHFR rs1801133 G>A p...

Let Gg,b be the set of all uni/trivalent graphs representing the combinatorial structures of pant decompositions of the oriented surface ⌃g,b of genus g with b boundary components. We describe the set Ag,b of all automorphisms of graphs in Gg,b showing that, up to suitable moves changing the graph within Gg,b, any such automorphism can be reduced to elementary switches of adjacent edges.

Purpose Previous studies investigating the association between interleukin-17A (IL-17A) G197A polymorphism and gastric cancer risk have provided inconsistent results. We, therefore, conducted this meta-analysis to clarify the association between IL-17A G197A polymorphism and gastric cancer risk. Methods We searched PubMed, Excerpta Medica Database, and CNKI databases to identify relevant stud...

BackgroundOssification of the posterior atlantoaxial membrane (PAAM) is a rare cause spinal cord compression.Case presentationA 46-year-old woman with rheumatoid arthritis (RA) and 2-year history slowly progressive gait disturbance underwent surgery for right knee stiffness lower limb mild weakness. A neurologic examination revealed brisk deep tendon reflexes (DTR) spasticity in her four limbs....

A genetic model-free method for the meta-analysis of genetic association studies is described that estimates the mode of inheritance from the data rather than assuming that it is known. For a bi-allelic polymorphism, with G as risk allele and g as wild-type, the genetic model depends on the ratio of the two log odds ratios, lambda = log OR(Gg)/log OR(GG), where OR(GG) compares GG with gg and OR...

We show that CG ({g}) is a subgroup CG ({g}) ≤ G. • Closure: For x, y ∈ GG ({g}), then xg = gx and yg = gy, so in particular gxy = xgy = xyg, so xy ∈ CG ({g}) • Inverses: For x ∈ CG ({g}) ⊆ G, ∃x−1 ∈ G s.t. xx−1 = x−1x = e, since G is a group. For g−1 ∈ G exists, then we can write gx−1g−1x = g (gx) x = g (xg) x = gg−1x−1x = e, which shows gx−1 = x−1g, so x−1 ∈ CG ({g}) • Identity: For e ∈ G, eg...

The SinI and EcoRII DNA methyltransferases recognize sequences (GG(A)/(T)CC and CC(A)/(T)GG, respectively), which are characterized by an (A)/(T) ambiguity. Recognition of the A.T and T.A base pair was studied by in vitro methyltransferase assays using oligonucleotide substrates containing a hypoxanthine.C base pair in the central position of the recognition sequence. Both enzymes methylated th...

AIM To determine whether -1195 A-->G and/or -765 G-->C polymorphisms in Cyclooxygenase-2 (COX-2) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population. METHODS Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area. DNA was isolated from whole bloo...

MiR-124 functions as a tumor suppressor and plays an important role in tumorigenesis. A common polymorphism (rs531564, C>G) in the pri-miR-124 has been recently studied in connection with cancer risk. The aim of the present study was to investigate the association between pri-miR-124 rs531564 polymorphism and the risk and clinicopathological characteristics of colorectal cancer (CRC). Two case-...