background: systemic lupus erythematosus is a systemic autoimmune disorder with unclear etiology. the importance of some genes in the development of systemic lupus erythematosus has been implicated. the gene polymorphism in codon 72 has attracted a lot of attention and its role in the occurrence or progression of many cancers and autoimmune diseases especially systemic lupus erythematosus has b...

Background: Systemic lupus erythematosus is a systemic autoimmune disorder with unclear etiology. The importance of some genes in the development of systemic lupus erythematosus has been implicated. The gene polymorphism in codon 72 has attracted a lot of attention and its role in the occurrence or progression of many cancers and autoimmune diseases especially systemic lupus erythematosus has ...

the gene tp53 (also known as protein 53 or tumor protein 53), encoding transcription factor p53, is mutated or deleted in half of human cancers, demonstrating the crucial role of p53 in tumor suppression. there are reports of nearly 250 independent germ line tp53 mutations in over 100 publications. the p53 protein has the structure of a transcription factor and, is made up of several domains. t...

Abstract P53 is frequently mutated in most human cancers, including glioblastoma (GBM). Many p53 mutants acquire gain-of-function oncogenic effects through only partially understood mechanisms. To investigate the role of mutant (MUT-p53) GBM, we performed ChIP-seq wildtype (WT-p53) and MUT-p53 GBM cell lines. Among 2834 unique peaks reads cells, found 242 long non-coding RNAs (lncRNAs) with up ...

p53 plays a critical role in tumor suppression and is the most frequently mutated gene human cancers. Most mutants (mutp53) are missense mutations thus expressed In cancers that retain wtp53, wtp53 activities downregulated through multiple mechanisms. For example, overexpression of negative regulators p53, MDM2/MDMX, can also efficiently destabilize inactivate wtp53. Therefore, both mutp53 have...

abstract objective: detection of p53 gene mutation on its codon 248 between iranian women with breast cancer by pcr-rflp. material and methods: dna extraction of tumor tissues was performed in 53 patients with primary breast cancer. designing primer for the sub-studying codon was performed with nti-vector software and detection of codon 248 mutation was done by msp i pcr_rflp. results: the soma...

aim : the propose of this study was to evaluate the probable correlation between exon and intron polymorphisms of p53 gene and their association with clinicopathological aspects of gastritis. background : regarding to the decisive role of p53 in the development of a variety of human cancers, a comprehensive study concerning probable correlation between polymorphisms in the p53 intron and exon i...

background: prostate cancer is one of the most commonly diagnosed cancers in males. tumor suppressor gene p53 plays an important role in causing cell cycle arrest and allowing apoptosis to proceed. objective: to investigate the expression of p53 protein and its relation to apoptosis and prostate cancer traditional prognostic indicators. methods: in this study expression of p53 was examined in p...

Background: Recent evidence suggests that regular exercise training is effective in treating various aspects of cancer. Therefore, the purpose of this study was to determine the effect of 8 weeks of aerobic interval training on monocarboxylate transporter 1 (MCT1) protein and expression of p53 gene in tumor of colon cancer mice. Methods: The present study was conducted experimentally from May ...