The suprachiasmatic nucleus (SCN) is the master circadian pacemaker. The pineal hormone melatonin is involved in the regulation of circadian phase. As a part of the circadian system, its synthesis and secretion is under SCN control. On the other hand, melatonin feeds back on the SCN to regulate its function. Melatonin has two specific windows of time at which it regulates SCN function, namely d...

For p > 0, let (Bn) and p(Bn) denote, respectively, the p-Bloch and holomorphic p-Lipschitz spaces of the open unit ball Bn in Cn. It is known that (Bn) and 1−p(Bn) are equal as sets when p ∈ (0,1). We prove that these spaces are additionally normequivalent, thus extending known results for n= 1 and the polydisk. As an application, we generalize work byMadigan on the disk by investigating bound...

UNLABELLED Myocardial infarction (MI) leads to left ventricular (LV) remodeling, which leads to the activation of growth factors such as vascular endothelial growth factor (VEGF). However, the kinetics of a growth factor's receptor expression, such as VEGF, in the living subject has not yet been described. We have developed a PET tracer (64Cu-DOTA-VEGF121 [DOTA is 1,4,7,10-tetraazadodecane-N,N'...

Chung, Diaconis, and Graham considered random processes of the form Xn+1 = anXn + bn (mod p) where p is odd, X0 = 0, an = 2 always, and bn are i.i.d. for n = 0, 1, 2, . . .. In this paper, we show that if P (bn = −1) = P (bn = 0) = P (bn = 1) = 1/3, then there exists a constant c > 1 such that c log2 p steps are not enough to make Xn get close to uniformly distributed on the integers mod p.

Rapidly activating and inactivating A-type K+ currents (IA) encoded by Kv4.2 and Kv4.3 pore-forming (α) subunits of the Kv4 subfamily are key regulators of neuronal excitability. Previous studies have suggested a role for Kv4.1 α-subunits in regulating the firing properties of mouse suprachiasmatic nucleus (SCN) neurons. To test this, we utilized an RNA-interference strategy to knockdown Kv4.1,...

Objective(s): Somatostatin receptor-positive neuroendocrine tumors have been targeted using various peptide analogs radiolabeled with therapeutic radionuclides for years. The better biomedical properties of radioantagonists as higher tumor uptake make these radioligands more attractive than agonists for somatostatin receptor-targeted radionuclide therapy. In this study...

OBJECTIVE To review the evidence for the validity and utility of subtyping bulimia nervosa (BN) into a purging (BN-P) and a nonpurging subtype (BN-NP), and of distinguishing BN-NP from binge eating disorder (BED), by comparing course, complications, and treatment. METHOD A literature search of psychiatry databases for studies published in peer-reviewed journals that used the DSM-definitions o...

For a finite n-element set X, n ≥ 1, let N [X] denote the number of elements of X and let p(n) denote the number of all partitions of X. If Bn is a Boolean algebra with n atoms, let A(Bn) be the set of all atoms of Bn. It is known that there exists a bijective correspondence between the set S(Bn) of all subalgebras of Bn and the set of all partitions of A(Bn), i.e., N [S(Bn)] = p(n). The follow...

BACKGROUND The circadian timing system controlled by the suprachiasmatic nuclei (SCN) of the hypothalamus regulates daily rhythms of motor activity and adrenocortical secretion. An alteration in these rhythms is associated with poor survival of patients with metastatic colorectal or breast cancer. We developed a mouse model to investigate the consequences of severe circadian dysfunction upon tu...

Peptide-receptor imaging and therapy with radiolabeled somatostatin analogs such as 68Ga-DOTA-TATE and 177Lu-DOTA-TATE have become an effective treatment option for SSTR-positive neuroendocrine tumors. The purpose of this study was to evaluate the correlation of somatostatin receptor-2 (SSTR2) expression with 68Ga-DOTA-TATE uptake and 177Lu-DOTA-TATE therapy in neuroblastoma (NB) xenograft mode...