This work approaches the P-median problem with a partitioning around medoids methodology. This problem has been extensively studied because of the multiple applications and its NP-hard nature; therefore several are the efforts to find optimal solutions. In this paper we consider two case studies: 1) instances from OR-Library and 2) geographical objects from the metropolitan zone of Toluca, Mexi...

The hub location problem is important in the selection of technological networks, such as computer, cellular, or wireless sensor networks. These modern communication networks must be dynamically set as triggered by changes in external conditions; the nodes deplete their batteries and go out of service. For this reason, it is necessary to update the available data in order to determine which nod...

Background The Lablite project captured information on access to antiretroviral therapy (ART) at larger health facilities ('hubs') and lower-level health facilities ('spokes') in Phalombe district, Malawi and in Kalungu district, Uganda. Methods We conducted a cross-sectional survey among patients who had transferred to a spoke after treatment initiation (Malawi, n=54; Uganda, n=33), patients...

In this paper, we propose the planar obnoxious facilities p-median problem. problem objective is to find p locations for that minimize weighted sum of distances between communities and their closest facility. version, add constraints each facility must be located at least a certain distance from partial set because they generate nuisance affecting these communities. The resulting extremely non-...

Although papillary renal cell carcinoma (PRCC) accounts for 10%-15% of renal cell carcinoma (RCC), no predictive molecular biomarker is currently applicable to guiding disease stage of PRCC patients. The mRNASeq data of PRCC and adjacent normal tissue in The Cancer Genome Atlas was analyzed to identify 1148 differentially expressed genes, on which weighted gene co-expression network analysis wa...

background: current who best infection control practices for injections do not address the use of hub cutters due to insufficient evidence on safety and efficacy. objective: to assess the impact of the use of hub cutters on 1) the frequency of needle-stick injuries (nsis) and other blood exposures among workers and 2) the volume of sharps waste in a mass vaccination campaign setting. methods: d...