copper-64 was produced in large scales and high specific activities in late 1990s’ using compact cyclotrons based by 64ni(p,n)64cu reaction and many radiopharmaceuticals developed since then by various groups based on interesting physicochemical and nuclear properties of the radionuclide. the unique emission of beta particles as well as positron particles offers a spectacular real therapeutic/d...

immune responses play critical roles in the leishmaniasis eradication. il-10 is a key regulator of immune responses, and the polymorphisms within its promoter region are associated with alteration in its expression. therefore, this study was designed to examine the correlation between polymorphism at the -1082 position of the il-10 gene and visceral leishmaniasis (vl).the il-10 -1082 polymorphi...

many species belonging to the scrophularia genus have been used since ancient times as folk remedies for many medical conditions such as scrofulas, scabies, tumors, eczema, psoriasis, inflammations. the aim of this study was to characterize the matrix metalloproteinases (mmps) inhibitor compounds of the scrophularia striata extract by bio-guide fractionation. the aerial parts of s. striata were...

objective(s):hypoxia induces cellular oxidative stress that is associated with neurodegenerative diseases. here, the protective effects of ferulic acid (fa) on hypoxia-induced neurotoxicity in pc12 cells were evaluated. materials and methods:we investigated the effect of fa on pc12 cells subjected to hypoxia stress, in vitro. results:fa increased cell viability, prevented membrane damage (ldh r...

drought resistance is a very important characteristic needed for plant survival especially at germination stage, in arid and semi-arid lands. phosphatase enzymes are widely found in plants. these enzymes are responsible for dephosphorylation of organic phosphate and altering it to mineral phosphate. germination experiments were conducted in two bread wheat cultivars (sardari and alvand) under s...

background α-adrenergic receptor 2a (adra2a) and angiotensin-converting enzyme (ace) genes have been variably associated with obesity and its related phenotypes in different populations worldwide. objectives this cross-sectional study aims to investigate the association of adrenergic receptor α2a (adra2a) rs553668 and angiotensin-converting enzyme (ace) i/d single nucleotide polymorphisms (snps...

presence of antibiotic resistance markers has always been considered as one of the main safety concerns in transgenic plants and their derived products. elimination of antibiotic selectable markers from transgenics is a major hurdle for finding efficient and safe candidates. herbicide tolerance genes might be attractive alternatives. in this study, a variant form of the 5-enoylpyruvyl shikimate...

background: pre-eclampsia (pe) is one of the most important and life-threatening pregnancy disorders that affect at least 3-5% of all pregnancies. imbalance in helper t cell functions may play a role in predisposing to pe or severity of the disease. elevated frequencies of th17 cells in the peripheral blood of pe patients have been reported. several single nucleotide polymorphisms (snp) within ...

alkaline phosphatase is an enzyme with widespread use in research and industry such as protein labeling, dephosphorylation of nucleic acids, and enzyme based biosensors. in the present study, alkaline phosphatase gene was inserted into the pet15b vector. the recombinant dna was then expressed using iptg as an inducer. the expression of this enzyme was optimized by changing expression conditions...

background: an amount of artificial radionuclide has been released into the environment as fallout, resulting from atmospheric nuclear weapon tests, nuclear accidents such as chernobyl and together with air currents have polluted the world. materials and methods: 37 surface soil samples of tehran province were collected in the period between june and september 2008, by implementing methods and ...